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Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial

Gray, Glenda E; Mngadi, Kathryn; Lavreys, Ludo; Nijs, Steven; Gilbert, Peter B; Hural, John; Hyrien, Ollivier; Juraska, Michal; Luedtke, Alex; Mann, Philipp; McElrath, M Juliana; Odhiambo, Jackline A; Stieh, Daniel J; Duijn, Janine van; Takalani, Azwidihwi N; Willems, Wouter; Tapley, Asa; Tomaras, Georgia D; Hoof, Johan Van; Schuitemaker, Hanneke; Swann, Edith; Barouch, Dan H; Kublin, James G; Corey, Lawrence; Pau, Maria G; Buchbinder, Susan; Tomaka, Frank.
Lancet, Infect. dis.; (), 2024
Background: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis in groups with high vulnerability can b...
AIDS Vaccines/administration & dosage, AIDS Vaccines/immunology, Adjuvants, Immunologic/administration & dosage, Double-Blind Method, HIV Antibodies/immunology, HIV Antibodies, HIV-1/immunology, Vaccine Efficacy, Mozambique
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Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses

Chissumba, Raquel Matavele; Luciano, Abílio; Namalango, Eduardo; Bauer, Asli; Bhatt, Nilesh; Wharen, Britta; Nilsson, Charlotta; Geldmacher, Christof; Scarlatti, Gabriella; Jani, Ilesh; Kastens, Luc.
Immunobiol., Suppl; 223 (12), 2018
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology, Antibodies, Neutralizing/immunology, CD4 Lymphocyte Count, Cytokines/biosynthesis, HIV Antibodies/immunology, HIV Infections/prevention & control, HIV Infections/virology, HIV-1/immunology, HIV-1/genetics, Mozambique, CD8-Positive T-Lymphocytes/immunology, T-Lymphocytes, Regulatory/metabolism, Vaccines, DNA/immunology, Vaccines, DNA/genetics
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Recent progress in immune-based interventions to prevent HIV-1 transmission to children

Voronin, yegor; Jani, ilesh; Graham, barney, s; Cunningham, coleen, k; Mofenson, lynne, m; Musoke, philippa, m; Permar, sallie, r; Scarlatti, gabriella.
J. int. aids soc; 20 (4), 2017
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approache...
HIV-1, HIV-1/immunology, AIDS Vaccines/administration & dosage, HIV Antibodies, AIDS Vaccines/immunology, HIV Infections, Antibodies, Neutralizing/immunology, HIV Antibodies/immunology, HIV Infections/immunology, HIV Infections/prevention & control, Infections/virology, Infectious Disease Transmission, Vertical/prevention & control
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