Alonso, Selena;
Vudal, Marta;
Olalla, Gemma Ruiz;
Gonzelez, Raquel;
Manaca, M. Nelia;
Jairoce, Chenjerai;
Santiago, Chenjerai;
Balcells, Reyes;
Vala, Anifa;
Ruperez, María;
Cistero, Pau;
Soro, Laura Fuente;
Cova, Marta;
Angov, Evelina;
Nhacolo, Arsenio;
Sevene, Esperança;
Aponte, John J;
Macete, Eusebio;
Aguilar, Ruth;
Mayor, Alfredo;
Menendez, Clara;
Dobano, Carlota;
Moncunil, Gemma.
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...
HIV,
Immunoglobulin G,
Antibodies, Monoclonal,
Malaria,
Schools, Nursery,
Blood-Borne Pathogens,
d0053120,
Placenta/immunology,
Placenta/metabolism,
Pregnancy,
HIV Infections/virology
Alonso, Selena;
Vudal, Marta;
Olalla, Gemma Ruiz;
Gonzelez, Raquel;
Manaca, M Nelia;
Jairoce, Chenjerai;
Balcells, Reyes;
Vala, Anifa;
Ruperez, María;
Soro, Laura Fuente;
Cova, Marta;
Angov, Evelina;
Nhacolo, Arsenio;
Sevene, Esperança;
Aponte, John J;
Macete, Eusebio;
Dobano, Carlota;
Moncunil, Gemma.
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...
Antibodies/immunology,
Antigens/immunology,
Antiretroviral Therapy, Highly Active,
Fetal Blood/immunology,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
HIV Infections/virology,
Immunity, Maternally-Acquired,
Immunoglobulin G/immunology,
Maternal-Fetal Exchange/immunology,
Placenta/metabolism,
Pregnancy,
Carrier Proteins,
Sex Factors,
Vaccines/immunology
Background: There is scare information about HIV co-infections with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) among People Who Inject Drugs (PWID) in Mozambique. This information is critical to ensure the treatment necessary to decrease the progression of liver disease and the transmission o...
Hepatitis B/epidemiology,
HIV,
Substance-Related Disorders,
Viral Load,
Ambulatory Care,
Hepatitis C,
Infections,
Prevalence,
Risk Factors,
Drug Users,
Coinfection/epidemiology,
Coinfection/psychology,
Coinfection/virology,
Drug Users/psychology,
Drug Users/statistics & numerical data,
Epidemics,
HIV Infections/epidemiology,
HIV Infections/psychology,
HIV Infections/virology,
Hepacivirus,
Hepatitis B/psychology,
Hepatitis B/virology,
Hepatitis B virus,
Hepatitis C/epidemiology
Vaz, paula;
Buck, w, chris;
Bhatt, Nilesh;
Bila, Dulce;
Auld, andrew;
Houston, James;
Cossa, loide;
Alfredo, Charity;
Jobarteh, kebba;
Sabatier, jennifer.
Background: Virologic failure (VF) is highly prevalent in sub-Saharan African children on antiretroviral therapy (ART) and is often associated with human immunodeficiency virus drug resistance (DR). Most children still lack access to routine viral load (VL) monitoring for early identification of treatmen...
Anti-Retroviral Agents/therapeutic use,
Drug Resistance, Viral,
HIV/radiation effects,
HIV Infections/therapy,
HIV Infections/virology,
Lamivudine/therapeutic use,
Lamivudine/pharmacology,
Nevirapine/pharmacology,
Nevirapine/therapeutic use,
Stavudine/pharmacology,
Stavudine/therapeutic use,
Viral Load
Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...
HIV Infections/diagnosis,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
HIV-1/physiology,
Infant, Newborn, Diseases/diagnosis,
Infant, Newborn, Diseases/virology,
Mozambique,
Sensitivity and Specificity,
Prospective Studies,
Viral Load/methods,
Viremia/diagnosis,
Viremia/virology
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
Chissumbam, raquel, matavele;
Namalango, eduardo;
Maphossa, vânia;
Macicame, ivalda;
Bhatt, nilesh;
Polyak, christina;
Michael, nelson;
Jani, ilesh, v;
Kestens, luc.
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology,
Flow Cytometry,
Forkhead Transcription Factors/immunology,
HIV Infections/immunology,
HIV-1/immunology,
Virus Replication,
Viral Load,
CD4-Positive T-Lymphocytes/virology,
CD4-Positive T-Lymphocytes/immunology,
HIV Infections/virology,
Ikaros Transcription Factor/genetics,
Minor Lymphocyte Stimulatory Antigens,
T-Lymphocytes, Regulatory/immunology,
T-Lymphocytes, Regulatory/virology,
Viral Replication Compartments/immunology,
Mozambique
Introduction: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to id...
Chang, joy;
Sousa, amina de;
Sabatier, jennifer;
Assane, mariamo;
Zhang, guoqing;
Bila, dulce;
Vaz, paula;
Alfredo, charity;
Cossa, Loide;
Bhatt, Nilesh;
Koumans, emilia, h;
Yang, chunfu;
Rivadeneira, emilia;
Jani, ilesh;
Houston, james, c.
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this st...
Peter, trevor;
Ellenberger, dennis;
Boeras, debrah;
Kim, andrea A;
Messele, tsehaynesh;
Roberts, teri;
Stevens, wendy;
Jani, ilesh;
Abimiku, alash'le;
Ford , nathan;
Katz, Zachary;
Nkengasong, john N.
Scaling up access to HIV viral load testing for individuals undergoing antiretroviral therapy in low-resource settings is a global health priority, as emphasised by research showing the benefits of suppressed viral load for the individual and the whole population. Historically, large-scale diagnostic tes...
Anti-HIV Agents/therapeutic use,
Antiretroviral Therapy, Highly Active/methods,
Drug Monitoring,
HIV Infections/drug therapy,
Health Policy,
Medical Laboratory Science,
Blood/virology,
Desiccation/methods,
Global Health,
HIV Infections/prevention & control,
HIV Infections/virology,
Medical Laboratory Science/organization & administration,
Specimen Handling/methods,
Viral Load
