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Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors
Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors

Oliveira, Michelle F; Ramalho, Dulce B; Abreu, Celina M; Vubil, Adolfo; Mabunda, Nédio; Tanuri, Amilcar; Jani, Ilesh.
AIDS res. hum. retrovir; 28 (12), 2012
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important arget antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy andelvitegravir is in the late phase of clinical development; both show good results in monot...
DNA, Viral/chemistry, DNA, Viral/genetics, Drug Resistance, Viral, Genetic Variation, HIV Infections/virology, HIV Integrase/genetics, HIV Integrase Inhibitors/therapeutic use, Molecular Sequence Data, Proviruses/genetics, Mutation, Missense, Mozambique/epidemiology, Sequence Analysis, DNA/instrumentation
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Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors

Oliveira, Michelli, F; Ramalho, Dulce, B; Abreu, Celina, M; Vubil, Adolfo Salvador; Mabunda, Nédio; Ismael, Nalia; Francisco, Cidia; Jani, Ilesh, V; Tanuri, Amilcar.
AIDS res. hum. retrovir; 28 (), 2012
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important target antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy and elvitegravir is in the late phase of clinical development; both show good results in mon...
DNA, Viral/genetics, HIV-1, DNA, Viral/chemistry, Mozambique, Drug Resistance, Viral, Genetic Variation, HIV Infections/virology, HIV Integrase/genetics, Molecular Sequence Data, Mutation, Proviruses/genetics, Sequence Analysis, DNA
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