Vubil, Adolfo;
Zicai, Ana Flora;
Sitoe, Nádia;
Nhachigule, Carina;
Costa, Paulino da;
Magul, Cacildo;
Meggi, Bindiya;
Viegas, Sofia;
Mabunda, Nédio;
Jani, Ilesh.
ABSTRACT Dried blood spot (DBS) may overestimate the viral RNA, mainly in patients
with low viral load (VL), due to proviral DNA and intracellular RNA. The Burnett and
HemaSpot provide integrated solutions for the collection, separation, and drying of
plasma from whole blood. This study aims to evalua...
In 2021, there were more than 150,000 new HIV infections among children; however, only 52% of children living with HIV were on antiretroviral treatment (ART) [1]. Untreated infants and young children are at high risk for rapid disease progression and death [2, 3]; early diagnosis and rapid treatment can ...
Objectives: Our study aimed to evaluate the stability of human immunodeficiency virus 1 (HIV-1) RNA on cobas plasma separation card (PSC) specimens for viral load (VL) testing after being exposed to varied temperatures and storage times.
Methods: For this purpose, venous PSC specimens were collected and ...
Nhampossa, Tacilta;
Fernández-Luis, Sheila;
Fuente-Soro, Laura;
Bernardo, Edson;
Nhacolo, Arsénio;
Orvalho, Augusto;
Nhacolo, Ariel;
Saura-Lázaro, Anna;
Lopez-Varela, Elisa;
Naniche, Denise.
Introduction: Manhiça District, in Southern Mozambique harbors high HIV prevalence and a long history of migration. To optimize HIV care, we sought to assess how caregiver's mobility impacts children living with HIV (CLHIV)´s continuation in HIV care and to explore the strategies used by caregivers to ...
Ambulatory Care Facilities,
Anti-HIV Agents/therapeutic use,
Anti-Retroviral Agents/administration & dosage,
Anti-Retroviral Agents/therapeutic use,
Caregiver Burden/psychology,
Caregivers/psychology,
HIV Infections/therapy,
HIV-1/pathogenicity,
Health Services Accessibility/trends,
Human Migration/trends,
Middle Aged,
Mozambique/epidemiology
Teasdale, Chloe A;
Brittain, Kirsty;
Zerbe, Allison;
Mellins, Claude Ann;
Falcao, Joana;
Couto, Aleny;
De Gusmao, Eduarda Pimentel;
Vitale, Mirriah;
Kapogiannis, Bill;
Simione, Teresa Beatriz;
Myer, Landon;
Mantell, Joanne;
Desmond, Christopher;
Abrams, Elaine J.
Background: Adolescents living with HIV (ALHIV) 15-19 years of age are a growing proportion of all people living with HIV globally and the population includes adolescents with vertically acquired HIV (AVH) and behaviorally acquired HIV (ABH).
Methods: We conducted a survey to measure sociodemographic ch...
Anti-Retroviral Agents/therapeutic use,
Condoms,
Educational Status,
HIV Infections/epidemiology,
HIV Infections/physiopathology,
HIV Infections/transmission,
HIV-1/pathogenicity,
Medical History Taking/statistics & numerical data,
Medication Adherence/statistics & numerical data,
Sexual Behavior/statistics & numerical data,
Mozambique/epidemiology
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...
HIV Infections/diagnosis,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
HIV-1/physiology,
Infant, Newborn, Diseases/diagnosis,
Infant, Newborn, Diseases/virology,
Mozambique,
Sensitivity and Specificity,
Prospective Studies,
Viral Load/methods,
Viremia/diagnosis,
Viremia/virology
Philips, Andrew N;
Cambiano, Valentina;
Nakagawa, Fumiyo;
Matharu, Loveleen Bansi;
Wilson, David;
Jani, Ilesh;
Apollo, Tsitsi;
Sculpher, Mark;
Hallett, Timothy;
Kerr, Cliff 2 7;
Ooterhout, Joep J van;
Eaton, Jeffrey W;
Estill, Janne 10 11;
Williams, Brian;
Doi, Naoko;
Cowan, Frances;
Keiser, Olivia;
Ford, Deborah;
Hatzold, Karin;
Barnabas, Ruanne;
Ayles, Helen;
Rath, Gesine Meyer;
Nelson, Lisa;
Johnson, Cheryl;
Baggaley, Rachel;
Fakoya, Ade;
Jahn, Andreas;
Revill, Paul.
Introduction: As prevalence of undiagnosed HIV declines, it is unclear whether testing programmes will be cost-effective. To guide their HIV testing programmes, countries require appropriate metrics that can be measured. The cost-per-diagnosis is potentially a useful metric.
Methods: We simulated a serie...
Africa, Southern,
Circumcision, Male,
d0000829220,
Cost-Benefit Analysis,
HIV Infections/diagnosis,
HIV Infections/epidemiology,
HIV-1,
Mass Screening/economics,
Poverty,
Pregnancy,
Risk Factors,
Sex Workers
Cunha, Lina;
Carrilho, Carla;
Bhatt, Nilesh;
Loforte, Michella;
Maueia, Cremildo;
Fernandes, Fabíola;
Guisseve, Assucena;
Mbofana, Francisco;
Maibaze, Fatima;
Mondlane, Liana;
Ismail, Muhammad;
Dimande, Luzmira;
Machatine, Sheila;
Lunet, Nuno;
Liu, YuTsueng;
Samo Gudo, Eduardo;
Pineau, Pascal.
Mozambique had been ranked among the countries with the highest
global incidence of HCC with chronic hepatitis B infection and high exposure to aflatoxin-B1
(AFB1) being major risk factors. Indeed, HCC remains one of the most frequent cancer in Maputo.
On the other hand, Mozambique has a high prevalence ...
Mozambique,
HIV,
Hepatitis B, Chronic,
Hepatitis B,
HIV-1,
Hepatitis Antibodies,
Hepatitis C Antibodies,
HIV Infections,
Hepatitis C,
Immunity
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
