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Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique

Alonso, Selena; Vudal, Marta; Olalla, Gemma Ruiz; Gonzelez, Raquel; Manaca, M Nelia; Jairoce, Chenjerai; Balcells, Reyes; Vala, Anifa; Ruperez, María; Soro, Laura Fuente; Cova, Marta; Angov, Evelina; Nhacolo, Arsenio; Sevene, Esperança; Aponte, John J; Macete, Eusebio; Dobano, Carlota; Moncunil, Gemma.
Front. immunol; 12 (), 2021
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...
Antibodies/immunology, Antigens/immunology, Antiretroviral Therapy, Highly Active, Fetal Blood/immunology, HIV Infections/therapy, HIV Infections/epidemiology, HIV Infections/immunology, HIV Infections/virology, Immunity, Maternally-Acquired, Immunoglobulin G/immunology, Maternal-Fetal Exchange/immunology, Placenta/metabolism, Pregnancy, Carrier Proteins, Sex Factors, Vaccines/immunology
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Invasive bacterial disease trends and characterization of group B streptococcal isolates among young infants in southern Mozambique, 2001-2015

Sigauque, Betuel; Kobayashi, Miwako; Vubil, Delfino; Nhacolo, Ariel; Chauque, Alberto; Moiane, Benild; Massora, Sérgio; Mandomando, Inácio; Nhampossa, Tacilta; Bassat, Quique; Pimenta, Fabiana; Menendez, Clara; Carvalho, Maria da Gloria; Macete, Eusebio; Schrag, Stephanie J.
PLoS One; 13 (1), 2018
Maternal group B streptococcal (GBS) vaccines under development hold promise to prevent GBS disease in young infants. Sub-Saharan Africa has the highest estimated disease burden, although data on incidence and circulating strains are limited. We described invasive bacterial disease (IBD) trends among inf...
Streptococcal Infections/epidemiology, Mozambique/epidemiology, Virulence/genetics, Penicillin Resistance, Bacterial Infections/epidemiology, Genome, Bacterial, Immunity, Maternally-Acquired, Incidence, Infant, Newborn, Microbial Sensitivity Tests, Multiplex Polymerase Chain Reaction, Penicillin Resistance/genetics, Penicillin-Binding Proteins/genetics, Point Mutation, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control, Streptococcal Vaccines/pharmacology, Streptococcus agalactiae/drug effects
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