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Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure

Valmaseda, aida; Macete, eusebio; Nhabomba, augusto; Guinovart, caterina; Aide, pedro; Bardají, azucena; Bassat, quique; Nhampossa, tacilta; Maculuve, sonia; Casellas, aina; Quintó, llorenç; Sanz, sergi; Jiménez, alfons; Feng, gaoqian; Langer, christine; Reiling, linda; Reddy, k, sony; Pandey, alok; Chitnis, chetan, e; Chauhan, virander, s; Aguilar, ruth; Aponte, john, j; Dobaño, carlota; Beeson, james, g; Gaur, deepak; Menéndez, clara; Alonso, pedro, l; Mayor, alfredo.
Clin. infect. dis; 66 (4), 2018
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
Adaptive Immunity, Age Factors, Antibodies, Protozoan/immunology, Antigens, Protozoan/immunology, Immunoglobulin G/immunology, Immunoglobulin M/immunology, Malaria Vaccines/immunology, Malaria, Falciparum/prevention & control, Plasmodium falciparum, Mozambique
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