Introdução: A malária é a principal causa de problemas de saúde em Moçambique, sendo responsável por cerca
de 40% de todas consultas externas nas unidades sanitárias do país. Este estudo visa analisar os processos de
crianças menores de 5 anos com diagnóstico de malária e convulsões, no dist...
Background: Plasmodium falciparum infection in pregnant women in sub-Saharan Africa is often asymptomatic. As these forms of malaria are often submicroscopic and difficult to diagnose by conventional methods (microscopy and/or rapid diagnostic test), diagnosis requires the use of molecular techniques suc...
Huijben, silvie;
Macete, eusebio;
Ngoma, ghyslain mombo;
Ramharter, michael;
Kariuki, Simon;
Desai, meghna;
Shi, ya ping;
Uberegui, estefania;
Mwangoka, grace;
Massougbodji, achille;
Cot, michel;
Ndam, nicaise tuikue;
Gupta, himanshu;
Cisteró, pau;
Aponte, john, j;
González, raquel;
Menéndez, clara;
Mayor, alfredo.
Background: Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.
Methods: Plasmod...
Antimalarials/therapeutic use,
Drug Combinations,
Drug Resistance, Multiple/drug effects,
Malaria, Falciparum/blood,
Mefloquine/therapeutic use,
Polymorphism, Genetic,
Malaria, Falciparum/drug therapy,
Malaria/epidemiology
Em Moçambique a malária é responsável por 60% de todas as admissões pediátricas, por 40% do total de consultas e ainda por 30% de todas as mortes registadas nos hospitais (2).Com vista a reverter esse cenário, o governo moçambicano, por intermédio do Programa Nacional de Combate à Malária (PCN...
Malaria/epidemiology,
Malaria, Avian,
Mozambique/epidemiology,
Artemether/therapeutic use,
Artemether/supply & distribution,
Lumefantrine/therapeutic use,
Lumefantrine/supply & distribution,
Medical Care/methods,
Malaria, Falciparum/diagnosis,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/transmission,
Anopheles/virology
Gupta, himanshu;
Macete, eusebio;
Bulo, helder;
Salvador, crizolgo;
Warsame, marian;
Carvalho, eva;
Ménard, didier;
Ringwald, pascal;
Bassat, quique;
Enosse, sonia;
Mayor, alfredo.
One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collect...
Nhama, Abel;
Bassat 1, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre...
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Artesunate/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Mozambique/epidemiology
Nhama, Abel;
Bassat, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentr...
Amodiaquine/adverse effects,
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Fluorenes/adverse effects,
Fluorenes/therapeutic use,
Kaplan-Meier Estimate,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Treatment Outcome,
Mozambique/epidemiology
A malária e HIV/SIDA representam os dois principais problemas de saúde pública no mundo. O efeito da imunodepressão causada pelo HIV/SIDA afecta a resposta imune do hospedeiro contra a malária; contudo estudos sobre o impactodo HIV/SIDA na resposta humoral contra Pl...
Malaria/prevention & control,
Malaria/complications,
Malaria/drug therapy,
Immunity, Humoral/immunology,
Antigens/administration & dosage,
Malaria, Falciparum/drug therapy,
Sexually Transmitted Diseases/transmission,
HIV,
Patients,
Morbidity/trends,
Mortality/trends
Quelhas, Diana;
Puyol, Laura;
Quinto, Llorenç;
Nhsmpossa, Tacilta;
Casas, Elisa Serra;
Macete, Eusébio;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Doolan, Denise L;
Menendez, Clara;
Dobano, Carlota.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Chloroquine/adverse effects,
Amodiaquine/administration & dosage,
Malaria, Falciparum/drug therapy,
Sulfadoxine/administration & dosage,
Antimalarials/administration & dosage,
Antimalarials/adverse effects,
Chloroquine/administration & dosage,
Malaria, Falciparum/therapy,
Plasmodium falciparum/radiation effects,
Pyrimethamine/administration & dosage,
Pyrimethamine/adverse effects,
Treatment Outcome
