Rapid diagnostic tests (RDTs) that detect the Plasmodium falciparum-specific histidine-rich protein 2 (PfHRP2) antigen are the primary methods for malaria diagnosis in Mozambique. However, these tests do not detect infections with non-falciparum malaria or Pfhrp2- and Pfhrp3-deleted P. falciparum parasit...
Gupta, himanshu;
Matambisso, gloria;
Galatas, beatriz;
Simone, wilson;
Nhamussua, lidia;
Cisteró, pau;
Cunningham, jane;
Rabinovich, N regina;
Saute, francisco;
Alonso, pedro L;
Aide, pedro;
Mayor, Alfredo.
Background: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnos tic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. Methods: Plasmodium...
Mayor, Alfredo;
Bardají, Azucena;
Macete, Eusebio;
Nhampossa, Tacilta;
Fonseca, Ana Maria;
González, Raquel;
Maculuve, Sonia;
Cisteró, Pau;
Rupérez, Maria;
Campo, Joe;
Vala, Anifa;
Sigaúque, Betuel;
Jiménez, Alfons;
Machevo, Sonia;
Fuente, Laura de la;
Nhama, Abel;
Luis, Leopoldina;
Aponte, John J;
Acácio, Sozinho;
Nhacolo, Arsenio;
Chitnis, Chetan;
Dobaño, Carlota;
Sevene, Esperanza;
Alonso, Pedro Luis;
Menéndez, Clara.
Background: Prevention of reinfection and resurgence is an integral component of the goal to eradicate malaria. However, the adverse effects of malaria resurgences are not known.
Methods: We assessed the prevalence of Plasmodium falciparum infection among 1819 Mozambican women who delivered infants betwe...
Antibodies, Protozoan/blood,
Immunoglobulin G/blood,
Malaria, Falciparum/classification,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Parasite Load,
Parity,
Plasmodium falciparum/immunology,
Plasmodium falciparum/isolation & purification,
Pregnancy Complications, Infectious/classification,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/immunology,
Severity of Illness Index
Moro, Laura;
Bardaji, Azucena;
Nhampossa, Tacilta;
Mandomando, Inácio;
Serra-Casas, Elisa;
Sigauque, Betuel;
Cistero, Pau;
Chauhan, Virander S;
Chitnis, Chetan E;
Ordi, Jaume;
Dobaño, Carlota;
Alonso, Pedro L;
Menendez, Clara;
Mayor, Alfredo.
Background. Malaria and human immunodeficiency virus (HIV) during pregnancy affect the transplacental transfer of antibodies against several pathogens from mother to fetus, although their effect over antimalarial antibodies remains unclear.
Methods. Total immunoglobulin G (IgG), IgM and IgG subtypes aga...
Malaria, Falciparum/immunology,
Pregnancy Complications, Parasitic/virology,
Pregnancy Complications, Parasitic/immunology,
Antibodies, Protozoan/blood,
Pregnancy Complications, Parasitic/microbiology,
Maternal-Fetal Exchange,
Infant, Newborn,
HIV Infections/immunology,
Mozambique/epidemiology,
Fetal Blood/immunology,
Coinfection/immunology,
Coinfection/virology,
Coinfection/parasitology
Nhabomba, augusto J;
Guinovart, caterina;
Dobaño, carlota;
Alonso, pedro L;
Chitnis, chetan E;
Mayor, alfredo;
Aponte, john J;
Bassat, quique;
Rodríguez, mauricio H;
Barbosa, arnoldo;
Aguila, ruth;
Cisteró, pau;
Quintó, llorenç;
Manaca, maria N;
Jiménez, alfons.
Background: The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has proven difficult to elucidate. A randomized, double-blind, placebo-controlled trial using monthly chemoprophylaxis with sulphadoxine-...
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Pyrimethamine/therapeutic use,
Sulfadoxine/therapeutic use,
Adaptive Immunity,
Antigens, Protozoan/immunology,
Environmental Exposure,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Enzyme-Linked Immunosorbent Assay,
Erythrocytes/parasitology,
Erythrocytes/immunology,
Chemoprevention
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Antibodies, Protozoan,
d0109630,
Antibodies, Protozoan/blood,
Antibody Formation/radiation effects,
Antigens, Protozoan/immunology,
Antigens, Surface/immunology,
Antineoplastic Combined Chemotherapy Protocols/chemistry,
Immunoglobulin G/blood,
Malaria, Falciparum/blood,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Membrane Proteins/immunology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/pathogenicity,
Protozoan Proteins/immunology,
Mozambique
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Antibodies, Protozoan/blood,
Antibodies, Protozoan/immunology,
Antibodies, Protozoan/genetics,
Antimalarials/administration & dosage,
Antimalarials/therapeutic use,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Plasmodium falciparum/immunology,
Pyrimethamine/administration & dosage,
Mozambique,
Recombinant Proteins/genetics,
Recombinant Proteins/immunology
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects,
Malaria, Falciparum/prevention & control,
Mozambique/epidemiology,
Child, Preschool,
Double-Blind Method,
Malaria Vaccines/administration & dosage,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology
Background
Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and th...
Age Factors,
Anemia,
Antigens, Protozoan/immunology,
Anemia/prevention & control,
Anemia/immunology,
Dapsone/therapeutic use,
Drug Therapy, Combination,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/epidemiology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/drug effects,
Tanzania/epidemiology,
Pyrimethamine/therapeutic use,
Treatment Outcome
Hogh, Birthe;
Thompson, Ricardo;
Lobo, Vitoria;
Dgedge, Martinho;
Dziegiel, Morten;
Borre, Martin;
Gottschau, Adam;
Streat, Elisabeth;
Schapira, Allan;
Barreto, Jorge.
We examined the impact of chemoprophylaxis on the cellular and humoral immune responses to polypeptides of the asexual Plasmodium falciparum blood stage antigens, the glutamate rich protein GLURP and Pf155/RESA, both of which in previous field studies have been identified as potentially protective antige...
Malaria, Falciparum/epidemiology,
Antimalarials/immunology,
Enzyme-Linked Immunosorbent Assay,
Antimalarials/therapeutic use,
Antibodies, Protozoan/immunology,
Antibodies, Protozoan/biosynthesis,
Mozambique/epidemiology,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Plasmodium falciparum/immunology,
Protozoan Proteins/immunology,
Pyrimethamine/therapeutic use,
Pyrimethamine/immunology,
Seasons,
Drug Combinations
