Djimde, Moussa;
Tshiongo, Japhet Kabalu;
Muhindo, Hypolite Mavoko;
Tinto, Halidou;
Sevene, Esperança;
Traore, aminata;
Vala, Anifa;
Macuacua, Salesio;
Kabore, Berenger;
Dabira, Edgard Diniba;
Erhart, Annette;
Diakite, Hamadoun;
Keita, Mohamed;
Piqueras, Mireia;
González, Raquel;
Menendez, clara;
Dorlo, Thomas Pc;
Sagara, Issaka;
Mens, Petra;
Schallig, Henk;
D'Alessandro, Umberto;
Kayentao, Kassoum.
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malaria, Falciparum/therapy,
Artemisinins/radiation effects,
Artemether, Lumefantrine Drug Combination,
Randomized Controlled Trials as Topic,
Pregnant Women,
Infection Control,
Parasitology,
Sub-Saharan African People,
Artemether/therapeutic use,
Antimalarials/radiation effects,
Mozambique/epidemiology
Silva , Clemente;
Boene, Simone;
Datta , Debayan;
Valbona, Eduard Rovira;
Díaz, Andrés Aranda 3 4;
Cisteró, Pau;
Hathaway , Nicholas;
Tessema, Sofonias;
Chidimatembue, Arlindo;
Matambisso, Glória;
Nhama, Abel;
Macete, Eusebio;
Pujol, Arnau;
Nhamussua , Lidia;
Galatas, Beatriz;
Guinovart, Caterina;
Enosse, Sónia;
Carvalho, Eva;
Rogier, Eric;
Plucinski, ateusz M;
Colborn, James;
Zulliger, Rose;
Saifodine, Abuchahama;
Alonso, Pedro L;
Candrinho , Baltazar;
Greenhouse , Bryan 3;
Saute, Francisco;
Mayor, Alfredo.
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 a...
Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquine,
Antimalarials/therapeutic use,
Drug Combinations,
Antimalarials/standards,
Parasitemia,
Treatment Outcome,
d0082880,
Artemether, Lumefantrine Drug Combination/pharmacology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Malaria, Falciparum/therapy,
Parasitemia/drug therapy,
Mozambique/epidemiology
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimalarials/therapeutic use,
Artemisinins/therapeutic use,
Malaria/epidemiology,
d0109630,
d0200660,
d0161330,
Artemether, Lumefantrine Drug Combination,
Drug Combinations,
Ethanolamines/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/genetics,
Polymerase Chain Reaction,
Mozambique/epidemiology
Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malaria, Falciparum/epidemiology,
Merozoite Surface Protein 1,
Plasmodium falciparum,
Protozoan Proteins,
Pyrimethamine,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Parasitemia/therapy,
Parasitemia/epidemiology,
Plasmodium falciparum/drug effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymerase Chain Reaction,
Pregnancy Complications, Parasitic/therapy,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/parasitology
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/mortality,
Malaria, Falciparum/physiopathology,
Malaria, Falciparum/therapy,
Multivariate Analysis,
Plasmodium falciparum/isolation & purification,
Mozambique/epidemiology,
Logistic Models,
Risk Factors,
Seasons,
Hospitalization
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Rural Health Services/statistics & numerical data,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Ambulatory Care Information Systems/statistics & numerical data,
Risk Factors,
Mozambique/epidemiology
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Chloroquine/adverse effects,
Amodiaquine/administration & dosage,
Malaria, Falciparum/drug therapy,
Sulfadoxine/administration & dosage,
Antimalarials/administration & dosage,
Antimalarials/adverse effects,
Chloroquine/administration & dosage,
Malaria, Falciparum/therapy,
Plasmodium falciparum/radiation effects,
Pyrimethamine/administration & dosage,
Pyrimethamine/adverse effects,
Treatment Outcome
Background: The observation of an increased prevalence of allergic disorders coinciding with a decreasing frequency of infectious diseases in early childhood has led to the speculation that infections may prevent allergic sensitization. Information on the role of parasites in this context is limited. Bro...
