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Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique

Silva , Clemente; Boene, Simone; Datta , Debayan; Valbona, Eduard Rovira; Díaz, Andrés Aranda 3 4; Cisteró, Pau; Hathaway , Nicholas; Tessema, Sofonias; Chidimatembue, Arlindo; Matambisso, Glória; Nhama, Abel; Macete, Eusebio; Pujol, Arnau; Nhamussua , Lidia; Galatas, Beatriz; Guinovart, Caterina; Enosse, Sónia; Carvalho, Eva; Rogier, Eric; Plucinski, ateusz M; Colborn, James; Zulliger, Rose; Saifodine, Abuchahama; Alonso, Pedro L; Candrinho , Baltazar; Greenhouse , Bryan 3; Saute, Francisco; Mayor, Alfredo.
Commun. biolog; 6 (1), 2023
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 a...
Antimalarials/pharmacology, Drug Resistance/genetics, Humans, Malaria/pathology, Malaria, Falciparum/prevention & control, Malaria, Falciparum/therapy
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Estimation of malaria-attributable fever in malaria test–positive febrile outpatients in three provinces of mozambique, 2018

Mateus, Plucinski; Baltazar, Candrinho; Marcia, Dimane; Tom, Smit; Julie, Thwing; James, Carbon; Rogier, Eric; Zullier, Rose.
Am. j. trop. med. hyg; 102 (1), 2020
Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test–positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology. We compared pan-Plasmodium a...
Malaria/diagnosis, Malaria/ethnology, Fever/ethnology, Malaria/epidemiology, Antigens, Protozoan/blood, Mozambique/epidemiology, Malaria/pathology, Outpatients
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