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Safety of the RTS, S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial
Safety of the RTS,S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial

Sacarlal, Jahit; Aponte, John J; Aide, Pedro; Mandomando, Inácio; Bassat, Quique; Guinovart, Caterina; Leach, Amanda; Milman, Jessica; Macete, Eusebio; Espasa, Mateu; Ofori-Anyinam, Opokua; Thonnard, Joelle; Corachan, Sabine; Dubois, Marie-Claude; Lievens, Marc; Dubovsky, Filip; Ballou, W Ripley; Cohen, Joe; Alonso, Pedro L.
Vaccine; 26 (2), 2008
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects, Malaria, Falciparum/prevention & control, Mozambique/epidemiology, Child, Preschool, Double-Blind Method, Malaria Vaccines/administration & dosage, Malaria, Falciparum/immunology, Malaria, Falciparum/epidemiology
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Safety of the RTS, S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial

Aponte , john J; Aide, pedro; Renom, montse; Mandomando, Inacio; Bassat, quique; Sacarlal, jahit; Manaca, nelia; Lafuente, sarah; Barbosa, arnoldo; Leach, amanda; Vekemans , johan; Lievens, marc; Sigauque, betuel; Dubois, marie-claude; Demoitié, marie ange; Sillman, marla; McNeil, john G; Savarese, barbara; Macete, eusebio; Cohen, joe; Ballou, W ripley; Alonso, pedro L.
Lancet; 370 (9598), 2007
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Antibodies, Protozoan/blood, Malaria/prevention & control, Malaria Vaccines/administration & dosage, Malaria Vaccines/adverse effects, Plasmodium falciparum/immunology, Mozambique
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