Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection
BMC immunol. (Online); 18 (1), 2017
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology, Flow Cytometry, Forkhead Transcription Factors/immunology, HIV Infections/immunology, HIV-1/immunology, Virus Replication, Viral Load, CD4-Positive T-Lymphocytes/virology, CD4-Positive T-Lymphocytes/immunology, HIV Infections/virology, Ikaros Transcription Factor/genetics, Minor Lymphocyte Stimulatory Antigens, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/virology, Viral Replication Compartments/immunology, Mozambique