Background: Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether–lumefantrine (AL) and amodiaquine–artesunate (AS–AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo...
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human
immunodeficiency virus (HIV)–positive patients are urgently needed.
Methods. At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tubercu...
Plasmodium falciparum immature gametocytes are not observed in peripheral blood. However, gametocyte stages in organs such as bone marrow have never been assessed by molecular techniques, which are more sensitive than optical microscopy. We quantified P falciparum sexual stages in bone marrow (n = 174) a...
Toxoplasmose é uma doença parasitária causada por Toxoplasma gondii (T. gondii). O T. gondii, em pacientes imunocompetentes, geralmente causa infecções assintomáticas e latentes. Em doentes imunocomprometidos, a reactivação de toxoplasmose latente no Sistema Nervoso Central (SNC), pode causar doe...
We performed a comparative analysis between Roche Amplicor HIV-1 DNA test and CAPTAQ assay for the detection of HIV in 830 dried blood spot (DBS) pediatric samples collected in Mozambique. Our results demonstrated no statistical difference between these assays. The CAPTAQ assay approached nearly 100% rep...
