Castro, Lucia Carratala;
Ssengooba, Willy;
Kay, Alex;
Acácio, Sozinho;
Ehrlich, Joanna;
DiNardo, Andrew R;
Shiba, Shiba;
Nsubuga, Joachim K;
Munguambe, Shilzia;
Cervera, Belén Saavedra;
Manjate, Patricia;
Mulengwa, Durbbin;
Sibandze, Busizwe;
Ziyane, Mangaliso;
Kasule, George;
Mambuque, Edson;
Sekadde, Moorine Penninah;
Wobudeya, Eric;
Joloba, Moses L;
Heyckendorf, Jan;
Lange, Christoph;
Hermans, Sabine;
Mandalakas, Anna;
Basteiro, Alberto L García;
Varela, Elisa Lopez.
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications,
Mycobacterium tuberculosis,
Tuberculosis/diagnosis,
Tuberculosis, Pulmonary/diagnosis,
HIV Infections/diagnosis,
Multicenter Studies as Topic,
Prospective Studies,
Sensitivity and Specificity,
Eswatini,
Mozambique,
Uganda
Barilar, ivan;
Fernando, Tatiana;
Utpatel, christian;
Abujate, cláudio;
Madeira, Carla, M;
José, benedita;
Mutaquiha, claudia;
Kranzer, katharina;
Niemann, tanja.
Background
In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Antitubercular Agents/pharmacology,
Antitubercular Agents/therapeutic use,
Fluoroquinolones/pharmacology,
Tuberculosis, Multidrug-Resistant,
Mozambique,
Mycobacterium tuberculosis/genetics,
Rifampin/therapeutic use,
Tuberculosis/therapy,
Tuberculosis, Multidrug-Resistant/therapy
Olbrich, laura;
Verghese, Valsan, P;
Smith, zoe franckling;
Sabi, issa;
Ntinginya, Nyanda E;
Mfinanga, alfred;
Banze, denise;
Viegas, sofia omar;
Khosa, celso;
Semphere, robina.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tuberculosis Host Response pr...
Azam, khalide;
Khosa, celso;
Viegas, sofia;
Massango, isabel;
Bhatt, nilesh;
Jani, ilesh;
Heinrich, Norbert;
Hoelscher, michael;
Gillespie, Stephen, H.
Background: Tuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid and quantitative biomarkers to monitor treatment response are urgently needed for individual patient management and clinical trials. C-reactive protein (CRP) is oft...
Cervera, Belén Saavedra;
López, Mariana G;
Chiner-Oms, Álvaro;
García, Ana Maria;
Cancino-Muñoz, Irving;
Torres-Puente, Manuela;
Villamayor, Luis;
Carlos Madrazo-Moya, Carlos;
Mambuque, Edson;
Sequera, Guilherme Victor;
Respeito, Durval;
Blanco, Sílvia;
Augusto, Orvalho;
López-Varela, Elisa;
Garcia-Basteiro, Alberto L;
Comas, Iñaki.
Genomic studies of the Mycobacterium tuberculosis complex (MTBC) might shed light on the dynamics of its transmission, especially in high-burden settings, where recent outbreaks are embedded in the complex natural history of the disease. To this end, we conducted a 1 year prospective surveillance-based ...
Shuaib, Yassir, A;
Utpatel, Christian;
Kohl, Thomas, A;
Barilar, Ivan;
Diricks, Margo;
Ashraf, Nadia;
Wieler, Lothar H;
Kerubo, Glennah;
Mesfin, Eyob, A;
Diallo, Awa Ba;
Frank, Matthias;
Khan, Sadiq, N.
Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents...
Balate, dionísia alfredo;
Manhiça, ivan;
Macuacua, bachir;
José, benedita;
Banze, denise;
Langa, josé carlos;
Baltazar, cynthia semá;
Sacarlal, jahit;
Rossetto, erika valeska;
Khosa, celso.
Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases in 2017. The aim of this study was to assess the surveillance system for multidrug-resist...
Antitubercular Agents/therapeutic use,
Databases, Factual,
Tuberculosis,
Tuberculosis, Multidrug-Resistant,
Mycobacterium tuberculosis,
Mozambique,
Tuberculosis, Multidrug-Resistant/diagnosis,
Tuberculosis, Multidrug-Resistant/therapy,
Tuberculosis, Multidrug-Resistant/epidemiology
A Tuberculose Extrapulmonar é uma infecção crónica causada pelo Mycobacterium tuberculosis, que afecta qualquer órgão fora da árvore brônquica–pulmonar, sendo mais incidente em países de baixa renda como Moçambique devido a prevalência aumentada de imunodeficiência grave por enfermidades e ...
Tuberculosis (TB) and malnutrition are important causes of morbidity and mortality in children in the developing world.
Aims
To assess the prevalence of pulmonary TB in severely malnourished children and evaluate TB detection using the urine lipoarabinomannan antigen assay (TB-LAM).
Methods
A retrospec...
HIV Infections,
Lipopolysaccharides,
Mycobacterium tuberculosis,
Sensitivity and Specificity,
Severe Acute Malnutrition,
Tuberculosis,
Tuberculosis, Pulmonary/diagnosis,
Tuberculosis, Pulmonary/complications,
Mozambique/epidemiology,
Tuberculosis, Pulmonary/epidemiology
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
