Results: 5

Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial

BMJ Open; 13 (10), 2023
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...

Field performance of ultrasensitive and conventional malaria rapid diagnostic tests in southern Mozambique

Malar. j. (Online); 19 (1), 2020
An ultrasensitive malaria rapid diagnostic test (RDT) was recently developed for the improved detection of low-density Plasmodium falciparum infections. This study aimed to compare the diagnostic performance of the PfHRP2-based Abbott Malaria Ag P. falciparum ultrasensitive RDT (uRDT) to that of the conv...

Estratégia Nacional dos Laboratórios Clínicos 2020-2024

Laboratórios clínicos desempenham um papel importante no apoio ao sistema do Serviço Nacional de Saúde, proporcionando saúde de qualidade para a população moçambicana. Como parte deste sistema, os laboratórios trabalham lado a lado com outros sectores para garantir testagem apropriada para o dia...

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection

Malar. j. (Online); 17 (1), 2018
Background: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to mal...

Placental pathology in malaria: A histological, immunohistochemical, and quantitative study*

Hum. pathol; 31 (1), 2000
Para caracterizar as alterações histológicas nas placentas da malária e sua relação com a paridade e parasitemias maternas e medulares, realizamos um estudo histológico em 1.179 placentas de Ifakara, na Tanzânia, uma área com transmissão intensa e perene da malária. Estudos imuno-histoquímico...