Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage,
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/administration & dosage,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Antineoplastic Combined Chemotherapy Protocols,
Drug Resistance/genetics,
Malaria/parasitology,
Malaria/prevention & control,
Mozambique,
Plasmodium falciparum/immunology,
Plasmodium falciparum/genetics,
Plasmodium falciparum/pathogenicity,
Polymorphism, Genetic,
Protozoan Proteins/genetics,
Protozoan Proteins/metabolism,
Quinolines/administration & dosage,
Quinolines/therapeutic use,
Quinolines/pharmacology
Mayor, alfredo;
Dobaño, carlota;
Nhabomba, augusto;
Guinovart, caterina;
Jiménez, alfonso;
Manaca, maria nelia;
Aguilar, ruth;
Barbosa, arnoldo;
Rodríguez, mauricio H;
Cisteró, pau;
Quimice, lazaro M;
Menéndez, clara;
Aponte, john J;
Ordi, jaume;
Chitnis, chetan E;
Alonso, pedro L.
Background: Difficulties to disentangle the protective versus exposure role of anti-malarial antibodies hamper the identification of clinically-relevant immune targets. Here, factors affecting maternal IgG and IgMs against Plasmodium falciparum antigens, as well as their relationship with parasite infect...
Malaria, Falciparum/diagnosis,
Mozambique,
Plasmodium falciparum/immunology,
Antibodies, Monoclonal,
Immunoglobulin G/metabolism,
Population Characteristics,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Pregnancy Complications, Parasitic/diagnosis,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/prevention & control,
Pregnancy Complications, Parasitic/parasitology,
Prevalence
Ndam, Nicaise Tuikue;
Mbuba, Emmanuel;
Gonzalez, Raquel 5;
Cistero, Pau;
Kariuki, Simon;
Sevene, Esperança;
Ruperez, María 5 6;
Fonseca, Ana Maria 5 9;
Vala, Anifa;
Muculuve, Sonia;
Jimenez, Alfons;
Quinto, Llorenç;
Ouma, Peter;
Ramharter, Michael;
Desai, Meghna;
Macete, Eusebio;
Cot, Michel;
Menendez, Clara;
Mayor, Alfredo.
Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malari...
HIV Infections/complications,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/transmission,
Microscopy,
Placenta,
Plasmodium falciparum/immunology,
Pregnancy Complications, Infectious,
Pregnancy Outcome,
Real-Time Polymerase Chain Reaction
A diversidade genética do Plasmodium falciparum é um dos maiores obstáculos para o desenvolvimento da imunidade assim como para a eficácia terapêutica de antimaláricos, pois confere ao parasita habilidade para evadir a resposta imune do hospedeiro, gerando mudanças na sua composição antigénica,...
Mayor, Alfredo;
Bardají, Azucena;
Macete, Eusebio;
Nhampossa, Tacilta;
Fonseca, Ana Maria;
González, Raquel;
Maculuve, Sonia;
Cisteró, Pau;
Rupérez, Maria;
Campo, Joe;
Vala, Anifa;
Sigaúque, Betuel;
Jiménez, Alfons;
Machevo, Sonia;
Fuente, Laura de la;
Nhama, Abel;
Luis, Leopoldina;
Aponte, John J;
Acácio, Sozinho;
Nhacolo, Arsenio;
Chitnis, Chetan;
Dobaño, Carlota;
Sevene, Esperanza;
Alonso, Pedro Luis;
Menéndez, Clara.
Background: Prevention of reinfection and resurgence is an integral component of the goal to eradicate malaria. However, the adverse effects of malaria resurgences are not known.
Methods: We assessed the prevalence of Plasmodium falciparum infection among 1819 Mozambican women who delivered infants betwe...
Antibodies, Protozoan/blood,
Immunoglobulin G/blood,
Malaria, Falciparum/classification,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Parasite Load,
Parity,
Plasmodium falciparum/immunology,
Plasmodium falciparum/isolation & purification,
Pregnancy Complications, Infectious/classification,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/immunology,
Severity of Illness Index
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Antibodies, Protozoan,
d0109630,
Antibodies, Protozoan/blood,
Antibody Formation/radiation effects,
Antigens, Protozoan/immunology,
Antigens, Surface/immunology,
Antineoplastic Combined Chemotherapy Protocols/chemistry,
Immunoglobulin G/blood,
Malaria, Falciparum/blood,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Membrane Proteins/immunology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/pathogenicity,
Protozoan Proteins/immunology,
Mozambique
Gillet, philippe;
Annelies, Scheirlinck;
Stokx, jocelijn;
Weggheleire, anja de;
Chaúque, hélder s;
Canhanga, oreana D J V;
Tadeu, benvindo t;
Mosse, carla d d;
Tiago, armindo;
Mabunda, Samuel;
Bruggeman, cathrien;
Bottieau, emmanuel;
Jacobs, jan.
Background: Prozone means false-negative or false-low results in antigen-antibody reactions, due to an excess of either antigen or antibody. The present study prospectively assessed its frequency for malaria rapid diagnostic tests (RDTs) and Plasmodium falciparum samples in an endemic field setting.
Met...
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Antibodies, Protozoan/blood,
Antibodies, Protozoan/immunology,
Antibodies, Protozoan/genetics,
Antimalarials/administration & dosage,
Antimalarials/therapeutic use,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Plasmodium falciparum/immunology,
Pyrimethamine/administration & dosage,
Mozambique,
Recombinant Proteins/genetics,
Recombinant Proteins/immunology
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Background
Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and th...
Age Factors,
Anemia,
Antigens, Protozoan/immunology,
Anemia/prevention & control,
Anemia/immunology,
Dapsone/therapeutic use,
Drug Therapy, Combination,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Malaria, Falciparum/epidemiology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/drug effects,
Tanzania/epidemiology,
Pyrimethamine/therapeutic use,
Treatment Outcome
