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Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

Gupta, himanshu; Bassat, quique; Nhamussua, lidia; Matambisso, gloria; Cisteró, pau; Huijben, silvie; Chidimatembue, arlindo; Galatas, beatriz; Ménard, didier; Ringwald, pascal; Rabinovich, regina; Alonso, pedro L; Saute, francisco; Assessor, pedro; Prefeito, alfredo.
PLos ONE; 15 (10), 2020
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage, Antimalarials/pharmacology, Antimalarials/therapeutic use, Artemisinins/administration & dosage, Artemisinins/pharmacology, Artemisinins/therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Drug Resistance/genetics, Malaria/parasitology, Malaria/prevention & control, Mozambique, Plasmodium falciparum/immunology, Plasmodium falciparum/genetics, Plasmodium falciparum/pathogenicity, Polymorphism, Genetic, Protozoan Proteins/genetics, Protozoan Proteins/metabolism, Quinolines/administration & dosage, Quinolines/therapeutic use, Quinolines/pharmacology
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In-vivo efficacy of chloroquine to clear asymptomatic infections in mozambican adults: a randomized, placebo-controlled Trial with Implications for Elimination Strategies

Galatas, beatriz; Nhamussua, lidia; Candrinho, baltazar; Mabote, lurdes; Cistero, pau; Gupta, himanshu; Rabinovich, regina; Menendez, clara; Macete, eusebio; Saute, francisco; Mayor, alfredo; Alonso, pedro; Bassat, quique; Aide, pedro.
Sci. rep. (Nat. Publ. Group); 7 (1356), 2017
Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was ...
Mozambique, Plasmodium falciparum/isolation & purification, Malaria, Falciparum, Drug Resistance, Antimalarials, Chloroquine/therapeutic use, Plasmodium falciparum/pathogenicity
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IgG against Plasmodium falciparum variant surface antigens and growth inhibitory antibodies in Mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine

Quelhas, Diana; Jimenez, Alfons; Quito, Llorenç; Casas, Elisa Serra; Mayor, Alfredo a d; Cistero, Pau; Puyol, Laura; Wilson, Danny W. e; Richards, Jack S; Nhampossa, Tacilta; Macete, Eusebioa; Aide, Pedro; Sanz, Sergi; Aponte, John J; Alonso, Pedro L; Beeson, James G; Menendez, Clara; Dobano, Carlota.
Immunobiology (1979); 216 (7), 2011
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Antibodies, Protozoan, d0109630, Antibodies, Protozoan/blood, Antibody Formation/radiation effects, Antigens, Protozoan/immunology, Antigens, Surface/immunology, Antineoplastic Combined Chemotherapy Protocols/chemistry, Immunoglobulin G/blood, Malaria, Falciparum/blood, Malaria, Falciparum/immunology, Malaria, Falciparum/epidemiology, Malaria, Falciparum/prevention & control, Membrane Proteins/immunology, Plasmodium falciparum/immunology, Plasmodium falciparum/pathogenicity, Protozoan Proteins/immunology, Mozambique
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