Valenciano, Sandra J;
Moiane, Benild;
Lessa, Fernanda C;
Chaúque, Alberto;
Massora, Sergio;
Pimenta, Fabiana C;
Mucavele, Helio;
Verani, Jennifer R;
Carvalho, Maria da Gloria;
Whitney, Cynthia G;
Tembe, Nelson;
Sigaúque, Betuel.
Pneumococcal pneumonia is the leading infectious cause of childhood mortality with an estimated 257 000 deaths globally among children aged 1–59 months in 2015 [1, 2]. Streptococcus pneumoniae is the most common cause of bacterial pneumonia in children [3]. HIV-infected children are at increased risk ...
Pimenta, Fabiana C;
Moiane, Benild;
Lessa, Fernanda C;
Venero, Anne-Kathryn L;
Moura, Iaci;
Larson, Shanda;
Massora, Sergio;
Chaúque, Alberto;
Tembe, Nelson;
Mucavele, Helio;
Verani, Jennifer R;
Whitney, Cynthia G;
Sigaúque, Betuel;
Carvalho, Maria G. S.
Background: Dried blood spots (DBS) have been proposed as potentially tool for detecting invasive bacterial diseases. Methods: We evaluated the use of DBS for S. pneumoniae and H. influenzae detection among children in Mozambique. Blood for DBS and nasopharyngeal (NP) swabs were collected from children w...
A meningite bacteriana é uma condição clínica que acarreta risco de vida, requerendo diagnóstico e tratamento precoces. Estima-se que ocorreram 2,8 milhões de casos de meningite em todo o mundo, em 2016 (Colaboradores GBDM Lancet 2018). Até 70% dos pacientes com meningite morrem sem tratamento (Ro...
Meningitis, Bacterial,
Meningitis/drug therapy,
Patients,
Meningitis/diagnosis,
Haemophilus influenzae,
Mozambique,
Health Surveillance System,
Hospitals/statistics & numerical data,
Health Personnel/statistics & numerical data,
Bacterial Vaccines/supply & distribution,
Noxae/supply & distribution,
Pneumococcal Infections/diagnosis,
Meningitis, Pneumococcal,
Vaccines/administration & dosage
A meningite bacteriana é uma condição clínica que acarreta risco de vida, requerendo diagnóstico e tratamento precoces. Estima-se que ocorreram 2,8 milhões de casos de meningite em todo o mundo, em 2016 (Colaboradores GBDM Lancet 2018). Até 70% dos pacientes com meningite morrem sem
tratamento (...
Meningitis, Bacterial,
Health Surveillance System,
Meningitis/diagnosis,
Meningitis/drug therapy,
Patients,
Mozambique,
Meningococcal Infections,
Haemophilus influenzae,
Pneumococcal Infections,
Vaccines/therapeutic use,
Vaccines/administration & dosage,
Immunization Programs,
Meningitis/prevention & control
Sigauque, betuel;
Moiane, benild;
Massora, sergio;
Pimenta, fabiana;
Verani, jennifer r;
Mucavele, helio;
Chauque, alberto;
Santos, rita t;
Carvalho, maria da gloria;
Whitney, cynthia g;
Leesa, fernanda c.
Pneumococcal carriage is a precursor of invasive pneumococcal disease. Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in April 2013, using a 3-dose schedule without a booster. We evaluated PCV10 impact on pneumococcal carriage and colonization density by HIV status.
Methods: We c...
Verani, jennifer r;
Massora, sérgio;
Acacio, sozinho;
Santos, rita teresa;
Vubil, delfino;
Pimenta, fabiana;
Moura, Iaci;
Whitney, cynthia g;
Costa, maria helena;
Macete, eusébio;
Matsinhe, Mmria benigna;
Carvalho, maria da gloria;
Sigauque, betuel.
Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV) impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected c...
Background: S. pneumoniae is the leading cause of acute bacterial meningitis (ABM) in children. Vaccination using the 10-valent conjugate vaccine (PCV-10) was recently introduced into the National Immunization Program in Mozambique, but data on serotype coverage of this vaccine formulation are scarce. In...
Anti-Bacterial Agents/pharmacology,
Pneumococcal Vaccines,
DNA, Bacterial/analysis,
Ceftriaxone/pharmacology,
Microbial Sensitivity Tests,
Drug Resistance, Multiple, Bacterial,
Epidemiological Monitoring,
Meningitis, Bacterial/epidemiology,
Meningitis, Bacterial/microbiology,
Meningitis, Bacterial/prevention & control,
Penicillins/pharmacology,
Pneumococcal Infections/immunology,
Pneumococcal Infections/microbiology,
Pneumococcal Vaccines/administration & dosage,
Streptococcus pneumoniae/classification,
Streptococcus pneumoniae/genetics,
Streptococcus pneumoniae/isolation & purification,
Streptococcus pneumoniae/radiation effects,
Polymerase Chain Reaction,
Mozambique/epidemiology
Valles, Xavier;
Flannery, Brendan;
Roca, Anna;
Mandomando, Inacio;
Sigauque, Betuel;
Sanz, Sergi;
Schuchat, Anne;
Levine, Myron;
Soriano-Gabarro, Montserrat;
Alonso, Pedro.
Objective: To describe and compare serotype distribution and antibiotic susceptibility of invasive and nasopharyngeal isolates of Streptococcus pneumoniae from children in rural Mozambique. Methods: From August 2002 to July 2003, we prospectively obtained invasive pneumococcal isolates from children <15 ...
Roca, A;
Sigaúque, B;
Quintó, Ll;
Mandomando, L;
Vallès, X;
Espasa, M;
Abacassamo, F;
Sacarlal, J;
Macete, E;
Nhacolo, A;
Levine, M;
Alonso, P.
Objectivos Estimar a incidência e as características epidemiológicas do pneumococo invasivodoença (DPI) em crianças de <5 anos de idade residentes em uma área rural do sul de Moçambique.Métodos Como parte do manejo clínico de crianças internadas em Manhiçum Hospital Distrital,A vigilância pr...
Meningitis, Pneumococcal,
Meningitis, Pneumococcal/epidemiology,
Chloramphenicol/therapeutic use,
Rural Population,
Mozambique/epidemiology,
Population Surveillance/methods,
Pneumococcal Infections/epidemiology,
Pneumonia/chemically induced,
Rural Health,
Anti-Infective Agents/therapeutic use
