To minimize the risk of vaccine-derived poliovirus emergences, the novel oral poliovirus vaccine type 2 (nOPV2), was bioengineered to have increased genetic stability compared to Sabin OPV and recommended for outbreak response Emergency Use Listing by WHO. Although pregnant women are not a target populat...
d0631300,
d0149300,
d0063010,
d0072300,
d0123060,
d0146150,
Mozambique,
Infant, Newborn/growth & development,
Longitudinal Studies,
Poliomyelitis/prevention & control,
Poliovirus Vaccine, Inactivated,
Poliovirus Vaccine, Oral/pharmacology,
Poliovirus,
Pregnancy,
Stillbirth/epidemiology
Cotugno, nicola;
Pallikkuth, suresh;
Sanna, marco;
Dinh, vinh 2;
Armas, lesley;
Rinaldi, stefano;
Davis, sheldon;
Linardos, giulia;
Pascucci, giuseppe rubens;
Pahwa, rajendra;
Sitoe, nadia;
Vaz, paula;
Rossi, paolo;
Lain, maria grazia;
Palma, paolo;
Pahwa, savita.
Despite antiretroviral treatment (ART), immune dysfunction persists in children with perinatal HIV infection (HEI). Here we investigated the impact of HIV status on maternal antibody (Ab) passage, long-term vaccine induced immunity and B-cell maturation.
Methods: 46 HIV Exposed Uninfected (HEU), 43 HEI,...
d0010710,
d0197410,
d0071090,
d0070720,
d0070740,
d0109490,
d0123130,
d0146110,
Anti-Retroviral Agents/therapeutic use,
Pregnancy,
Mozambique
Background: Plasmodium falciparum infection in pregnant women in sub-Saharan Africa is often asymptomatic. As these forms of malaria are often submicroscopic and difficult to diagnose by conventional methods (microscopy and/or rapid diagnostic test), diagnosis requires the use of molecular techniques suc...
Background Postpartum contraceptive uptake reduces short interpregnancy intervals, unintended pregnancies, and their negative sequalae: poor maternal and fetal outcomes. Healthy timing and spacing of pregnancy in people living with HIV (PLHIV) also allows time to achieve viral suppression to reduce paren...
Levy, karen;
Garn, joshua V;
Cumbe, zaida adriano;
Muneme, bacelar;
Fagnant-Sperati, christine s;
Hubbard, Sydney;
Júnior, antonio;
Manuel, joão luís;
Mangamela, Magalhães;
McGunegill, sandy;
Miller-Petrie, molly k;
Snyder, jedidiah s;
Victor, courtney;
Waller, lance a;
Konstantinidis, konstantinos t;
Clasen, thomas f;
Brown, joe;
Nalá, rassul;
Freeman, matthew c.
Introduction: Despite clear linkages between provision of clean water and improvements in child health, limited information exists about the health impacts of large water infrastructure improvements in low-income settings. Billions of dollars are spent annually to improve urban water supply, and rigorou...
Water Supply/methods,
Cohort Studies,
Ethics Committees, Research,
Gastrointestinal Microbiome,
Humans,
Infant,
Mozambique,
Pregnancy,
Prospective Studies,
Waterborne Diseases/transmission,
d0148810
Pons-Duran, Clara;
Mombo-Ngoma, Ghyslain;
Macete, Eusébio;
Desai, Meghna;
Kakolwa, Mwaka A;
Zoleko-Manego, Rella;
Ouédragou, Smaïla;
Briand, Valérie;
Valá, valá;
Kabanywanyi, Abdunoor M;
Ouma, Peter;
Massougbodji, Achille;
Sevene, Esperança;
Cot, Michel;
Aponte, John J;
Mayor, Alfredo;
Slutsker, Laurence;
Ramharter, Michael;
Menéndez, Clara;
González, Raquel.
Malaria is among the top causes of death in adolescent girls (10 to 19 years) globally. Adolescent motherhood is associated with increased risk of adverse maternal and neonatal outcomes. The interaction of malaria, adolescence, and pregnancy is especially relevant in malaria endemic areas, where rates of...
A mulher grávida, ao se deparar com as transformações físicas, hormonais, psíquicas e de inserção social, vivencia a manifestação de sintomas de transtornos mentais, no pré-natal, dentre eles a ansiedade e a depressão. O objetivo geral desta pesquisa foi avaliar a presença de indicadores de a...
Depression/psychology,
Anxiety/therapy,
Pregnancy,
Social Support,
Anxiety/drug therapy,
Mozambique,
Patient Health Questionnaire/standards,
Mental Health Assistance,
Depression/drug therapy,
d0113200,
ddcs0500840,
d0491680
Bone, jeffrey, n;
Magee, laura, a;
Singer, joel;
Nathan, hannah;
Qureshi, rahat, n;
Sacoor, charfudin;
Sevene, esperança;
Shennan, andrew;
Bellad, mrutyunjaya, b;
Goudar, shivaprasad, s;
Mallapur, ashalata, a;
Munguambe, khátia;
Vidler, marianne;
Dadelszen, peter von;
Bhutta, zulfiqar, a.
Background: Blood pressure measurement is a marker of antenatal care quality. In well resourced settings, lower blood pressure cutoffs for hypertension are associated with adverse pregnancy outcomes. We aimed to study the associations between blood pressure thresholds and adverse outcomes and the diagnos...
Sub-Saharan Africa concentrates the burden of HIV and the highest adolescent fertility rates. However, there is limited information about the impact of the interaction between adolescence and HIV infection on maternal health in the region. Data collected prospectively from three clinical trials conducted...
HIV Infections/complications,
Maternal Health/statistics & numerical data,
Pregnancy,
Infant Mortality/trends,
d0112530,
d0066780,
Mozambique/epidemiology,
HIV Infections/transmission,
HIV Infections/mortality,
Risk,
Mozambique/epidemiology,
Gestational Age,
Premature Birth/drug therapy
Alonso, Selena;
Vudal, Marta;
Olalla, Gemma Ruiz;
Gonzelez, Raquel;
Manaca, M. Nelia;
Jairoce, Chenjerai;
Santiago, Chenjerai;
Balcells, Reyes;
Vala, Anifa;
Ruperez, María;
Cistero, Pau;
Soro, Laura Fuente;
Cova, Marta;
Angov, Evelina;
Nhacolo, Arsenio;
Sevene, Esperança;
Aponte, John J;
Macete, Eusebio;
Aguilar, Ruth;
Mayor, Alfredo;
Menendez, Clara;
Dobano, Carlota;
Moncunil, Gemma.
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...
HIV,
Immunoglobulin G,
Antibodies, Monoclonal,
Malaria,
Schools, Nursery,
Blood-Borne Pathogens,
d0053120,
Placenta/immunology,
Placenta/metabolism,
Pregnancy,
HIV Infections/virology
