Home > > Search result

Results: 2

Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

Gupta, himanshu; Bassat, quique; Nhamussua, lidia; Matambisso, gloria; Cisteró, pau; Huijben, silvie; Chidimatembue, arlindo; Galatas, beatriz; Ménard, didier; Ringwald, pascal; Rabinovich, regina; Alonso, pedro L; Saute, francisco; Assessor, pedro; Prefeito, alfredo.
PLos ONE; 15 (10), 2020
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage, Antimalarials/pharmacology, Antimalarials/therapeutic use, Artemisinins/administration & dosage, Artemisinins/pharmacology, Artemisinins/therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Drug Resistance/genetics, Malaria/parasitology, Malaria/prevention & control, Mozambique, Plasmodium falciparum/immunology, Plasmodium falciparum/genetics, Plasmodium falciparum/pathogenicity, Polymorphism, Genetic, Protozoan Proteins/genetics, Protozoan Proteins/metabolism, Quinolines/administration & dosage, Quinolines/therapeutic use, Quinolines/pharmacology
Fulltext

Multi-Country Evaluation of Safety of Dihydroartemisinin/Piperaquine Post-Licensure in African Public Hospitals with Electrocardiograms

Kabanywanyi, Abdunoor M; Baiden, Rita; Ali, Ali M; Mahende, Muhidin K; Ogutu, Bernhards R; Oduro, Abraham; Tinto, Halidou; Gyapong, Margaret; Sie, Ali; Sevene, Esperanca; Macete, Eusebio; Agyei, Seth Owusu; Adjei, Alex; Compaoré, Guillaume; Valea, Innocent; Osei, Isaac; Yawson, Abena; Adjuik, Martin; Akparibo, Raymond; Kakolwa, Mwaka A; Abdulla, Salim; Binka, Fred.
PloS one; 10 (11), 2016
The antimalarial drug piperaquine is associated with delayed ventricular depolarization, causing prolonged QT interval (time taken for ventricular de-polarisation and re-polarisation). There is a lack of safety data regarding dihydroartemisinin/piperaquine (DHA/PPQ) for the treatment of uncomplicated mal...
Antimalarials/metabolism, Artemisinins/pharmacology, Heart/drug effects, Quinolines/pharmacology, Antimalarials/pharmacology, Antimalarials/therapeutic use, Artemisinins/therapeutic use, Black People, Blood Cell Count, Blood Chemical Analysis, Burkina Faso, Electrocardiography, Malaria/therapy, Mozambique/ethnology
Fulltext