Results: 11

Genetic characterisation of south african and mozambican bovine rotaviruses reveals a typical bovine-like artiodactyl constellation derived through multiple reassortment events

PloS pathog; 20 (2), 2022
This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without prior adaptation to cell culture, was used to synthesise cDNA using a self-annealing anchor primer ligated to dsRNA and random hexamers. The cDNA...

Sucessos e desafios da implementação da Vigilância Nacional de Diarreias (ViNaDia) em Moçambique

Introdução: o Instituto Nacional de Saúde de Moçambique, implementou a Vigilância Nacional de Diarreias (ViNa Dia) em 2014 cujo principal objectivo é determinar a carga de diarreias em crianças dos 0 aos 14 anos de idade, e os agentes etiológicos associados, em quatro províncias de Moçambique....

A narrative review on Rotavirus A in Mozambique

Introduction: Rotavirus A (RVA) is a leading cause of acute infant gastroenteritis in Mozambique, responsible for approximately 13,000 annual infant deaths in peri-urban and other areas. Aim: the present review aimed summarize the most relevant and recent literature regarding RVA infection in Mozambique....

Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea – a crosssectional study in four provinces of Mozambique

BMC infect. dis; 21 (18), 2021
Background: Mozambique has a high burden of group A rotavirus (RVA) infection and chronic undernutrition. This study aimed to determine the frequency and potential risk factors for RVA infection in undernourished children under 5 years old with diarrhoea in Mozambique. Methods: The analysis was conducted...

Rotavirus disease burden pre-vaccine introduction in young children in Rural Southern Mozambique, an area of high HIV prevalence

PLoS One; 16 (4), 2021
Rotavirus vaccines have been adopted in African countries since 2009, including Mozambique (2015). Disease burden data are needed to evaluate the impact of rotavirus vaccine. We report the burden of rotavirus-associated diarrhea in Mozambique from the Global Enteric Multicenter Study (GEMS) before vaccin...

Molecular epidemiology of rotavirus a strains pre- and post-vaccine (rotarix®) introduction in mozambique, 2012–2019: emergence of genotypes g3p[4] and g3p[8]

PloS pathog; 9 (), 2020
Group A rotavirus (RVA) remains the most important etiological agent associated with severe acute diarrhea in children. Rotarix® monovalent vaccine was introduced into Mozambique’s Expanded Program on Immunization in September 2015. In the present study, we report the diversity and prevalence of rotav...

Whole genome characterization and evolutionary analysis of g1p[8] rotavirus a strains during the pre- and post-vaccine periods in mozambique (2012–2017)

PloS pathog; 9 (), 2020
Mozambique introduced the rotarix® vaccine (gsk biologicals, rixensart, belgium) into the na-tional immunization program in september 2015. Although g1p[8] was one of the most prevalent genotypes between 2012 and 2017 in mozambique, no complete genomes had been sequenced to date. here we report whole ge...

Whole genome analyses of DS-1-like Rotavirus A strains detected in children with acute diarrhoea in southern Mozambique suggest several reassortment events

Infect. gent. evol; 69 (), 2019
Rotavirus (RV) is an important enteric pathogen in the young of many mammalian and avian species. The virus belongs to the Reoviridae family and contains an 11-segmented double-stranded RNA (dsRNA) genome. The dsRNA segments encode six structural (VP1–4, 6 and 7) and six non-structural (NSP1–5/6) pro...

Frequencia e caracterização dos genótipos de rotavirus do grupo A em crianças de 0 a 59 meses de idade, atendidas com diarreeia aguda na pediatria do Hospital Central de Nampula, 2015

A doença diarreica na infância constitui um importante problema de saúde pública em Moçambique. A infecção pelo Rotavirus é a uma das causas mais comum de diarreia aguda grave a nível mundial, sendo a diarreia terceira causa de morbi-mortalidade infantil na maioria d...

Rotavirus a strains obtained from children with acute gastroenteritis in mozambique, 2012-2013: g and p genotypes and phylogenetic analysis of vp7 and partial vp4 genes

Arch. virol; 163 (1), 2018
In Mozambique rotavirus (RV) was shown to be the greatest cause of acute diarrhoea in infants from 0 to 11 months, and in 2015, national rotavirus vaccination was introduced. As with other developing countries, there is very limited active strain characterisation. Rotavirus positive clinical specimens, c...