Castro, Lucia Carratala;
Ssengooba, Willy;
Kay, Alex;
Acácio, Sozinho;
Ehrlich, Joanna;
DiNardo, Andrew R;
Shiba, Shiba;
Nsubuga, Joachim K;
Munguambe, Shilzia;
Cervera, Belén Saavedra;
Manjate, Patricia;
Mulengwa, Durbbin;
Sibandze, Busizwe;
Ziyane, Mangaliso;
Kasule, George;
Mambuque, Edson;
Sekadde, Moorine Penninah;
Wobudeya, Eric;
Joloba, Moses L;
Heyckendorf, Jan;
Lange, Christoph;
Hermans, Sabine;
Mandalakas, Anna;
Basteiro, Alberto L García;
Varela, Elisa Lopez.
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications,
Mycobacterium tuberculosis,
Tuberculosis/diagnosis,
Tuberculosis, Pulmonary/diagnosis,
HIV Infections/diagnosis,
Multicenter Studies as Topic,
Prospective Studies,
Sensitivity and Specificity,
Eswatini,
Mozambique,
Uganda
Tuberculosis (TB) and malnutrition are important causes of morbidity and mortality in children in the developing world.
Aims
To assess the prevalence of pulmonary TB in severely malnourished children and evaluate TB detection using the urine lipoarabinomannan antigen assay (TB-LAM).
Methods
A retrospec...
HIV Infections,
Lipopolysaccharides,
Mycobacterium tuberculosis,
Sensitivity and Specificity,
Severe Acute Malnutrition,
Tuberculosis,
Tuberculosis, Pulmonary/diagnosis,
Tuberculosis, Pulmonary/complications,
Mozambique/epidemiology,
Tuberculosis, Pulmonary/epidemiology
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...
HIV Infections/diagnosis,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
HIV-1/physiology,
Infant, Newborn, Diseases/diagnosis,
Infant, Newborn, Diseases/virology,
Mozambique,
Sensitivity and Specificity,
Prospective Studies,
Viral Load/methods,
Viremia/diagnosis,
Viremia/virology
Floridia, Marco;
Ciccacci, Fausto;
Andreotti, Mauro;
Hassane, Archa;
Sidumo, Zita;
Magid, Nurja A;
Sotomane, Horacio;
David, Muhlavasse;
Mutemba, Elsa;
Cebola, Junia;
Mugunhe, Remigio José;
Riccardi, Fabio;
Marazzi, Maria Cristina;
Giuliano, Marina;
Palombi, Leonardo;
Mancinelli, Sandro.
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human
immunodeficiency virus (HIV)–positive patients are urgently needed.
Methods. At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tubercu...
Algorithms,
Antiretroviral Therapy, Highly Active,
Antitubercular Agents,
HIV Infections/drug therapy,
Lipopolysaccharides,
Molecular Diagnostic Techniques,
Mozambique,
Mycobacterium tuberculosis,
Prevalence,
Sensitivity and Specificity,
Tuberculosis, Pulmonary/diagnosis,
Sputum
Chang, joy;
Sousa, amina de;
Sabatier, jennifer;
Assane, mariamo;
Zhang, guoqing;
Bila, dulce;
Vaz, paula;
Alfredo, charity;
Cossa, Loide;
Bhatt, Nilesh;
Koumans, emilia, h;
Yang, chunfu;
Rivadeneira, emilia;
Jani, ilesh;
Houston, james, c.
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this st...
Menendez, Clara;
Castillo, Paola;
Martinez, Miguel;
Jordao, Dercio;
Lovane, Lucilia;
Ismael, Mamudo R;
Carrilho, Carla;
Lorenzoni, Cesaltina;
Fernandes, Fabiola;
Nhampossa, Tacilta 2 8;
Hurtado, Juan Carlos;
Navarro, Mireia;
Casas, Isaac;
Ritchie, Paula Santos;
Bandeira, Sonia;
Mucumbi, Sibone;
Jaze, Zara;
Mabota, Flora;
Munguambe, Khátia;
Maixenchs, Maria;
Sanz, Ariadna;
Mandomando, Inacio;
Nadal, Alfons;
Gonce, Anna;
Almagro, Carmen Muñoz;
Quinto, Llorenç;
Vila, Jordi;
Macete, Eusebio;
Alonso, Pedro;
Ordi, Jaume;
Bassat, Quique.
Over 5 million stillbirths and neonatal deaths occur annually. Limited and imprecise information on the cause of these deaths hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for cause of death determination-are difficult to perform in most high-...
Bassat, Quique;
Castillo, Paola;
Martínez, miguel, j;
Jordao, dercio;
Lucilia, lovane;
Hurtado, juan carlos;
Nhampossa, tacilta;
Ritchie, paula, santos;
Bandeira, sónia;
Sambo, Calvino;
Chicamba, valeria;
Ismail, mamudo, r;
Carrilho, carla;
Lorenzoni, cesaltina;
Fernandes, fabiola;
Cisteró, Pau;
Mayor, alfredo;
Cossa, Anelsio;
Mandomando, inacio;
Navarro, mireia;
Casas, isaac;
Vila, jordi;
Munguambe, khátia;
Maixenchs, maria;
Sanz, ariadna;
Quintó, llorenç;
Macete, eusebio;
Alonso, pedro;
Menéndez, clara;
Ordi, jaume.
Background: In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently u...
Jani, ilesh, v;
Meggi, bindiya;
Vubil, adolfo;
Bhatt, nilesh;
Tobaiwa, ocean;
Quevedo, jorge, i;
Loquiha, osvaldo;
Lehe, jonathan, d;
Vojnov, lara;
Peter, trevor, f.
Viral load testing is the WHO-recommended monitoring assay for patients on HIV antiretroviral therapy (ART). Point-of-care (POC) assays may help improve access to viral load testing in resource-limited settings. We compared the performance of the Alere Q NAT POC viral load technology (Alere Technologies,...
Background In resource-limited countries, CD4 T-cell (CD4) testing continues to be used for determining antiretroviral therapy (ART) initiation eligibility and opportunistic infection monitoring. To support expanded access to CD4 testing, simple and robust technologies are necessary. We conducted this st...
Sensitivity and Specificity,
Reproducibility of Results,
Mozambique,
Middle Aged,
Men,
Humans,
HIV Seropositivity,
Allergy and Immunology,
Child, Preschool,
CD4 Lymphocyte Count/instrumentation,
HIV Infections/immunology
