Castro, Lucia Carratala;
Ssengooba, Willy;
Kay, Alex;
Acácio, Sozinho;
Ehrlich, Joanna;
DiNardo, Andrew R;
Shiba, Shiba;
Nsubuga, Joachim K;
Munguambe, Shilzia;
Cervera, Belén Saavedra;
Manjate, Patricia;
Mulengwa, Durbbin;
Sibandze, Busizwe;
Ziyane, Mangaliso;
Kasule, George;
Mambuque, Edson;
Sekadde, Moorine Penninah;
Wobudeya, Eric;
Joloba, Moses L;
Heyckendorf, Jan;
Lange, Christoph;
Hermans, Sabine;
Mandalakas, Anna;
Basteiro, Alberto L García;
Varela, Elisa Lopez.
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications,
Mycobacterium tuberculosis,
Tuberculosis/diagnosis,
Tuberculosis, Pulmonary/diagnosis,
HIV Infections/diagnosis,
Multicenter Studies as Topic,
Prospective Studies,
Sensitivity and Specificity,
Eswatini,
Mozambique,
Uganda
Augusto, Ângelo do Rosário;
Nnaemeka, Nnaemeka C;
Kohatsu, Luciana;
Sousa, Leonardo de;
Maueia, Cremildo;
Hara, Cristina;
Mula, Flora;
Cuamba, Gércio;
Chelene, Imelda;
Langa, Zainabo;
Lohman, Nathaniel;
Faife, Flávio;
Giles, Denise;
Sabonete, Acácio José;
Gudo, Eduardo Samo;
Jani, Ilesh;
Parekh, Bharat S.
Effective implementation of the national Human Immunodeficiency Virus (HIV) programs require monitoring the HIV epidemic trends to identify programmatic successes, challenges, and needed improvements. HIV prevalence estimates, defined as the percentage of a population affected by HIV, are calculated by t...
Tuberculosis (TB) and malnutrition are important causes of morbidity and mortality in children in the developing world.
Aims
To assess the prevalence of pulmonary TB in severely malnourished children and evaluate TB detection using the urine lipoarabinomannan antigen assay (TB-LAM).
Methods
A retrospec...
HIV Infections,
Lipopolysaccharides,
Mycobacterium tuberculosis,
Sensitivity and Specificity,
Severe Acute Malnutrition,
Tuberculosis,
Tuberculosis, Pulmonary/diagnosis,
Tuberculosis, Pulmonary/complications,
Mozambique/epidemiology,
Tuberculosis, Pulmonary/epidemiology
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...
HIV Infections/diagnosis,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
HIV-1/physiology,
Infant, Newborn, Diseases/diagnosis,
Infant, Newborn, Diseases/virology,
Mozambique,
Sensitivity and Specificity,
Prospective Studies,
Viral Load/methods,
Viremia/diagnosis,
Viremia/virology
Floridia, Marco;
Ciccacci, Fausto;
Andreotti, Mauro;
Hassane, Archa;
Sidumo, Zita;
Magid, Nurja A;
Sotomane, Horacio;
David, Muhlavasse;
Mutemba, Elsa;
Cebola, Junia;
Mugunhe, Remigio José;
Riccardi, Fabio;
Marazzi, Maria Cristina;
Giuliano, Marina;
Palombi, Leonardo;
Mancinelli, Sandro.
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human
immunodeficiency virus (HIV)–positive patients are urgently needed.
Methods. At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tubercu...
Algorithms,
Antiretroviral Therapy, Highly Active,
Antitubercular Agents,
HIV Infections/drug therapy,
Lipopolysaccharides,
Molecular Diagnostic Techniques,
Mozambique,
Mycobacterium tuberculosis,
Prevalence,
Sensitivity and Specificity,
Tuberculosis, Pulmonary/diagnosis,
Sputum
Chang, joy;
Sousa, amina de;
Sabatier, jennifer;
Assane, mariamo;
Zhang, guoqing;
Bila, dulce;
Vaz, paula;
Alfredo, charity;
Cossa, Loide;
Bhatt, Nilesh;
Koumans, emilia, h;
Yang, chunfu;
Rivadeneira, emilia;
Jani, ilesh;
Houston, james, c.
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this st...
Menendez, Clara;
Castillo, Paola;
Martinez, Miguel;
Jordao, Dercio;
Lovane, Lucilia;
Ismael, Mamudo R;
Carrilho, Carla;
Lorenzoni, Cesaltina;
Fernandes, Fabiola;
Nhampossa, Tacilta 2 8;
Hurtado, Juan Carlos;
Navarro, Mireia;
Casas, Isaac;
Ritchie, Paula Santos;
Bandeira, Sonia;
Mucumbi, Sibone;
Jaze, Zara;
Mabota, Flora;
Munguambe, Khátia;
Maixenchs, Maria;
Sanz, Ariadna;
Mandomando, Inacio;
Nadal, Alfons;
Gonce, Anna;
Almagro, Carmen Muñoz;
Quinto, Llorenç;
Vila, Jordi;
Macete, Eusebio;
Alonso, Pedro;
Ordi, Jaume;
Bassat, Quique.
Over 5 million stillbirths and neonatal deaths occur annually. Limited and imprecise information on the cause of these deaths hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for cause of death determination-are difficult to perform in most high-...
Bassat, Quique;
Castillo, Paola;
Martínez, miguel, j;
Jordao, dercio;
Lucilia, lovane;
Hurtado, juan carlos;
Nhampossa, tacilta;
Ritchie, paula, santos;
Bandeira, sónia;
Sambo, Calvino;
Chicamba, valeria;
Ismail, mamudo, r;
Carrilho, carla;
Lorenzoni, cesaltina;
Fernandes, fabiola;
Cisteró, Pau;
Mayor, alfredo;
Cossa, Anelsio;
Mandomando, inacio;
Navarro, mireia;
Casas, isaac;
Vila, jordi;
Munguambe, khátia;
Maixenchs, maria;
Sanz, ariadna;
Quintó, llorenç;
Macete, eusebio;
Alonso, pedro;
Menéndez, clara;
Ordi, jaume.
Background: In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently u...
Meggi, Bindiya;
Bollinger, Timothy;
Mabunda, Nédio;
Vubil, Adolfo;
Tobaiwa, Ocean;
Quevedo, Jorge I;
Loquiha, Osvaldo;
Vojnov, Lara;
Peter, Trevor F;
Jani, Ilesh V.
The long delay in returning test results during early infant diagnosis of HIV (EID) often
causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited
settings. A point-of-care (POC) test may help overcome these challenges. We evaluated
the performance of the LYNX p24 A...
Anti-HIV Agents/therapeutic use,
Early Diagnosis,
HIV Infections/diagnosis,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
Point-of-Care Testing/standards,
Reproducibility of Results,
Mozambique/epidemiology,
Sensitivity and Specificity,
HIV-1/immunology
