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Genetic analysis and natural polymorphisms in HIV-1 gp41 isolates from Maputo City, Mozambique

Ismael, Nália; Bila, Dulce; Mariani, Diana; Vubil, Adolfo; Mabunda, Nedio; Abreu, Celina; Jani, Ilesh; Tanuri, Amilcar.
AIDS res. hum. retrovir; 30 (6), 2014
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
HIV-1/genetics, Amino Acid Sequence, Anti-HIV Agents, Cluster Analysis, Drug Resistance, Viral, Enfuvirtide, Genotype, HIV Envelope Protein gp41/genetics, HIV Infections/virology, HIV-1/classification, Molecular Sequence Data, Mozambique, Mutation, Missense, Peptide Fragments, Phylogeny, Polymorphism, Genetic, RNA, Viral, Sequence Alignment, Sequence Analysis, DNA, Treatment Failure
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Genetic Analysis and Natural Polymorphisms in HIV-1 gp41 Isolates from Maputo City, Mozambique

Ismael, Nália; Bila, Dulce; Mariana, Diana; Vubil, Adolfo; Mabunda, Nedio; Abreu, Celina; Ines, Ilesh; Tanuri, Amilcar.
AIDS res. hum. retrovir; 30 (6), 2013
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
Mozambique, Infections, HIV-1/growth & development, Circumcision, Male, Molecular Sequence Data, Polymorphism, Genetic, Treatment Failure, Sequence Analysis, DNA, Genotype, Drug Resistance, Viral, HIV Infections
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Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors
Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors

Oliveira, Michelle F; Ramalho, Dulce B; Abreu, Celina M; Vubil, Adolfo; Mabunda, Nédio; Tanuri, Amilcar; Jani, Ilesh.
AIDS res. hum. retrovir; 28 (12), 2012
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important arget antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy andelvitegravir is in the late phase of clinical development; both show good results in monot...
DNA, Viral/chemistry, DNA, Viral/genetics, Drug Resistance, Viral, Genetic Variation, HIV Infections/virology, HIV Integrase/genetics, HIV Integrase Inhibitors/therapeutic use, Molecular Sequence Data, Proviruses/genetics, Mutation, Missense, Mozambique/epidemiology, Sequence Analysis, DNA/instrumentation
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Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors

Oliveira, Michelli, F; Ramalho, Dulce, B; Abreu, Celina, M; Vubil, Adolfo Salvador; Mabunda, Nédio; Ismael, Nalia; Francisco, Cidia; Jani, Ilesh, V; Tanuri, Amilcar.
AIDS res. hum. retrovir; 28 (), 2012
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important target antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy and elvitegravir is in the late phase of clinical development; both show good results in mon...
DNA, Viral/genetics, HIV-1, DNA, Viral/chemistry, Mozambique, Drug Resistance, Viral, Genetic Variation, HIV Infections/virology, HIV Integrase/genetics, Molecular Sequence Data, Mutation, Proviruses/genetics, Sequence Analysis, DNA
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