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Invasive bacterial disease trends and characterization of group B streptococcal isolates among young infants in southern Mozambique, 2001-2015

Sigauque, Betuel; Kobayashi, Miwako; Vubil, Delfino; Nhacolo, Ariel; Chauque, Alberto; Moiane, Benild; Massora, Sérgio; Mandomando, Inácio; Nhampossa, Tacilta; Bassat, Quique; Pimenta, Fabiana; Menendez, Clara; Carvalho, Maria da Gloria; Macete, Eusebio; Schrag, Stephanie J.
PLoS One; 13 (1), 2018
Maternal group B streptococcal (GBS) vaccines under development hold promise to prevent GBS disease in young infants. Sub-Saharan Africa has the highest estimated disease burden, although data on incidence and circulating strains are limited. We described invasive bacterial disease (IBD) trends among inf...
Streptococcal Infections/epidemiology, Mozambique/epidemiology, Virulence/genetics, Penicillin Resistance, Bacterial Infections/epidemiology, Genome, Bacterial, Immunity, Maternally-Acquired, Incidence, Infant, Newborn, Microbial Sensitivity Tests, Multiplex Polymerase Chain Reaction, Penicillin Resistance/genetics, Penicillin-Binding Proteins/genetics, Point Mutation, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control, Streptococcal Vaccines/pharmacology, Streptococcus agalactiae/drug effects
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Frequency of Pathogenic Paediatric Bacterial Meningitis in Mozambique: The Critical Role of Multiplex Real-Time Polymerase Chain Reaction to Estimate the Burden of DiseaseFrequency of Pathogenic Paediatric Bacterial Meningitis in Mozambique: The Critical Role of Multiplex Real-Time Polymerase Chain Reaction to Estimate the Burden of Disease

Nhantumbo, aquino albino; Cantarelli, vlademir vicente; Caireão, juliana; Munguambe, alcides moniz; Comé, charlotte elizabeth; Pinto, gabriela do carmo; Zimba, tomás francisco; Mandomando, inácio; Semá, cynthia baltazar; Gudo, eduardo samo; Moraes, milton ozório.
PLos ONE; 10 (9), 2015
Background: In Sub-Saharan Africa, including Mozambique, acute bacterial meningitis (ABM) represents a main cause of childhood mortality. The burden of ABM is seriously underestimated because of the poor performance of culture sampling, the primary method of ABM surveillance in the region. Low quality ce...
DNA, Bacterial/cerebrospinal fluid, DNA, Bacterial/genetics, Drug Resistance, Bacterial, Haemophilus influenzae/drug effects, Haemophilus influenzae/genetics, Haemophilus influenzae/isolation & purification, Meningitis, Bacterial/diagnosis, Meningitis, Bacterial/epidemiology, Meningitis, Bacterial/microbiology, Microbial Sensitivity Tests, Multivariate Analysis, Neisseria meningitidis/drug effects, Neisseria meningitidis/genetics, Neisseria meningitidis/isolation & purification, Real-Time Polymerase Chain Reaction/methods, Reproducibility of Results, Seasons, Sensitivity and Specificity, Severity of Illness Index, Streptococcus agalactiae/drug effects, Streptococcus agalactiae/genetics, Streptococcus agalactiae/isolation & purification, Streptococcus pneumoniae/drug effects, Streptococcus pneumoniae/genetics, Streptococcus pneumoniae/isolation & purification, Mozambique/epidemiology
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