Castro, Lucia Carratala;
Ssengooba, Willy;
Kay, Alex;
Acácio, Sozinho;
Ehrlich, Joanna;
DiNardo, Andrew R;
Shiba, Shiba;
Nsubuga, Joachim K;
Munguambe, Shilzia;
Cervera, Belén Saavedra;
Manjate, Patricia;
Mulengwa, Durbbin;
Sibandze, Busizwe;
Ziyane, Mangaliso;
Kasule, George;
Mambuque, Edson;
Sekadde, Moorine Penninah;
Wobudeya, Eric;
Joloba, Moses L;
Heyckendorf, Jan;
Lange, Christoph;
Hermans, Sabine;
Mandalakas, Anna;
Basteiro, Alberto L García;
Varela, Elisa Lopez.
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications,
Mycobacterium tuberculosis,
Tuberculosis/diagnosis,
Tuberculosis, Pulmonary/diagnosis,
HIV Infections/diagnosis,
Multicenter Studies as Topic,
Prospective Studies,
Sensitivity and Specificity,
Eswatini,
Mozambique,
Uganda
Introduction
Mozambique has a high burden of Tuberculosis (TB) with an incidence of 368 per 100,000 population in 2020, coupled with a low all-form TB detection rate. The COVID-19 pandemic has exacerbated delays in timely diagnosis and treatment of new TB cases. Promoting active TB case finding is a nati...
Barilar, ivan;
Fernando, Tatiana;
Utpatel, christian;
Abujate, cláudio;
Madeira, Carla, M;
José, benedita;
Mutaquiha, claudia;
Kranzer, katharina;
Niemann, tanja.
Background
In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Antitubercular Agents/pharmacology,
Antitubercular Agents/therapeutic use,
Fluoroquinolones/pharmacology,
Tuberculosis, Multidrug-Resistant,
Mozambique,
Mycobacterium tuberculosis/genetics,
Rifampin/therapeutic use,
Tuberculosis/therapy,
Tuberculosis, Multidrug-Resistant/therapy
Olbrich, laura;
Verghese, Valsan, P;
Smith, zoe franckling;
Sabi, issa;
Ntinginya, Nyanda E;
Mfinanga, alfred;
Banze, denise;
Viegas, sofia omar;
Khosa, celso;
Semphere, robina.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tuberculosis Host Response pr...
As pessoas vivendo com HIV (PVHIV), incluindo as populações - chave para o HIV e os pacientes com tuberculose (TB), sofrem, muitas vezes, violação dos seus direitos humanos devido ao estigma e à discriminação associados à doença e às barreiras ligadas ao sistema de saúde que incluem, por exemp...
HIV,
Tuberculosis,
Human Rights,
Health Systems,
Ethics,
Primary Prevention,
Disease,
Therapeutics,
Trust,
Patients,
Social Discrimination,
Mozambique
Azam, khalide;
Khosa, celso;
Viegas, sofia;
Massango, isabel;
Bhatt, nilesh;
Jani, ilesh;
Heinrich, Norbert;
Hoelscher, michael;
Gillespie, Stephen, H.
Background: Tuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid and quantitative biomarkers to monitor treatment response are urgently needed for individual patient management and clinical trials. C-reactive protein (CRP) is oft...
Cervera, Belén Saavedra;
López, Mariana G;
Chiner-Oms, Álvaro;
García, Ana Maria;
Cancino-Muñoz, Irving;
Torres-Puente, Manuela;
Villamayor, Luis;
Carlos Madrazo-Moya, Carlos;
Mambuque, Edson;
Sequera, Guilherme Victor;
Respeito, Durval;
Blanco, Sílvia;
Augusto, Orvalho;
López-Varela, Elisa;
Garcia-Basteiro, Alberto L;
Comas, Iñaki.
Genomic studies of the Mycobacterium tuberculosis complex (MTBC) might shed light on the dynamics of its transmission, especially in high-burden settings, where recent outbreaks are embedded in the complex natural history of the disease. To this end, we conducted a 1 year prospective surveillance-based ...
Introdução: A Tuberculose (TB) continua sendo um grande problema de saúde pública em Moçambique, constando na lista das principais causas de morte nas nossas unidades sanitárias. A Organização Mundial de Saúde (OMS) recomenda o tratamento profiláctico com isoniazida (TPI) em pessoas infectadas ...
Balate, dionísia alfredo;
Manhiça, ivan;
Macuacua, bachir;
José, benedita;
Banze, denise;
Langa, josé carlos;
Baltazar, cynthia semá;
Sacarlal, jahit;
Rossetto, erika valeska;
Khosa, celso.
Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases in 2017. The aim of this study was to assess the surveillance system for multidrug-resist...
Antitubercular Agents/therapeutic use,
Databases, Factual,
Tuberculosis,
Tuberculosis, Multidrug-Resistant,
Mycobacterium tuberculosis,
Mozambique,
Tuberculosis, Multidrug-Resistant/diagnosis,
Tuberculosis, Multidrug-Resistant/therapy,
Tuberculosis, Multidrug-Resistant/epidemiology
Izco, Santiago;
Murias-Closas, Adrià;
Jordan, Alexander M;
Greene, Gregory;
Catorze, Nteruma;
Chiconela, Helio;
Garcia, Juan Ignacio;
Blanco-Arevalo, Alejandro;
Febrer, Anna;
Casellas, Aina;
Saavedra, Belén;
Chiller, Tom;
Nhampossa, Tacilta;
Garcia-Basteiro, Alberto;
Letang, Emilio.
Introduction: AIDS-mortality remains unacceptably high in sub-Saharan Africa, largely driven by advanced HIV disease (AHD). We nested a study in an existing tuberculosis (TB) contact-tracing intervention (Xpatial-TB). The aim was to assess the burden of AHD among high-risk people living with HIV (PLHIV) ...
