Castro, Lucia Carratala;
Ssengooba, Willy;
Kay, Alex;
Acácio, Sozinho;
Ehrlich, Joanna;
DiNardo, Andrew R;
Shiba, Shiba;
Nsubuga, Joachim K;
Munguambe, Shilzia;
Cervera, Belén Saavedra;
Manjate, Patricia;
Mulengwa, Durbbin;
Sibandze, Busizwe;
Ziyane, Mangaliso;
Kasule, George;
Mambuque, Edson;
Sekadde, Moorine Penninah;
Wobudeya, Eric;
Joloba, Moses L;
Heyckendorf, Jan;
Lange, Christoph;
Hermans, Sabine;
Mandalakas, Anna;
Basteiro, Alberto L García;
Varela, Elisa Lopez.
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications,
Mycobacterium tuberculosis,
Tuberculosis/diagnosis,
Tuberculosis, Pulmonary/diagnosis,
HIV Infections/diagnosis,
Multicenter Studies as Topic,
Prospective Studies,
Sensitivity and Specificity,
Eswatini,
Mozambique,
Uganda
Introduction
Mozambique has a high burden of Tuberculosis (TB) with an incidence of 368 per 100,000 population in 2020, coupled with a low all-form TB detection rate. The COVID-19 pandemic has exacerbated delays in timely diagnosis and treatment of new TB cases. Promoting active TB case finding is a nati...
Olbrich, laura;
Verghese, Valsan, P;
Smith, zoe franckling;
Sabi, issa;
Ntinginya, Nyanda E;
Mfinanga, alfred;
Banze, denise;
Viegas, sofia omar;
Khosa, celso;
Semphere, robina.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tuberculosis Host Response pr...
Musisi, Emmanuel;
Wyness, Adam;
Eldirdiri, Sahar;
Dombay, Evelin;
Mtafya, Bariki;
Ntinginya, Nyanda E;
Heinrich, Norbert;
Kibiki, Gibson S;
Hoelscher, Michael;
Boeree, Martin;
Aarnoutse, Rob;
Gillespie, Stephen H;
Sabiiti, Wilber.
Background: Respiratory tract microbiota has been described as the gatekeeper for respiratory health. We aimed to assess the impact of standard-of-care and experimental anti-tuberculosis treatment regimens on the respiratory microbiome and implications for treatment outcomes.
Methods: In this retrospect...
Manhiça, Ivan;
Augusto, Orvalho;
Sherr, Kenneth;
Cowan, James;
Cuco, Rosa Marlene;
Agostinho, Sãozinha;
Macuacua, Bachir C;
Carimo, Naziat;
Matsinhe, Maria Benigna;
Gloyd, Stephen;
Chicumbe, Sergio;
Machava, Raimundo;
Tembe, Stélio;
Fernandes, Quinhas;
Ramiro, Isaías.
Introduction Currently, COVID- 19 dominates the public health agenda and poses a permanent threat, leading to health systems’ exhaustion and unprecedented service disruption. Primary healthcare services, including tuberculosis services, are at increased risk of facing severe disruptions, particularly i...
Izco, Santiago;
Murias-Closas, Adrià;
Jordan, Alexander M;
Greene, Gregory;
Catorze, Nteruma;
Chiconela, Helio;
Garcia, Juan Ignacio;
Blanco-Arevalo, Alejandro;
Febrer, Anna;
Casellas, Aina;
Saavedra, Belén;
Chiller, Tom;
Nhampossa, Tacilta;
Garcia-Basteiro, Alberto;
Letang, Emilio.
Introduction: AIDS-mortality remains unacceptably high in sub-Saharan Africa, largely driven by advanced HIV disease (AHD). We nested a study in an existing tuberculosis (TB) contact-tracing intervention (Xpatial-TB). The aim was to assess the burden of AHD among high-risk people living with HIV (PLHIV) ...
Background Mozambique is one of the countries with the deadly implementation gaps in the tuberculosis (TB) care and services delivery. In-hospital delays in TB diagnosis and treatment, transmission and mortality still persist, in part, due to poor-quality of TB care cascade. Objective We aimed to assess,...
National Health Programs/trends,
Quality of Health Care/trends,
Tuberculosis/epidemiology,
Attitude of Health Personnel,
Equipment and Supplies, Hospital/trends,
Health Facilities,
Health Personnel/psychology,
Hospitals,
Mozambique/epidemiology,
Tuberculosis/diagnosis
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
Menéndez, clara;
Quintó, ilorenç;
Castillo, paola;
Carrilho, carla;
Ismail, mamudo, r;
Lorenzoni, cesaltina;
Fernandes, fabiola;
Hurtado, juan carlos;
Rakislova, natalia;
Munguambe, khátia;
Maixenchs, maria;
Macete, eusebio;
Mandomando, inacio;
Martínez, miguel, j;
Bassat, quique;
Alonso, pedro, i;
Ordi, jaume.
Background: Accurate information on causes of death (CoD) is essential to estimate burden of disease, track global progress, prioritize cost-effective interventions, and inform policies to reduce mortality. In low-income settings, where a significant proportion of deaths take place at home or in poorly-r...
Autopsy/methods,
Cause of Death/trends,
Rural Population,
Pneumonia/diagnosis,
Clinical Diagnosis,
Tuberculosis/diagnosis,
Health Facilities,
HIV/growth & development,
Mortality/trends,
Population,
Mozambique/epidemiology
Na estrutura do Ministério da Saúde, o programa nacional de controlo de ITS-HIV/SIDA (PNC ITS HIV/SIDA) representa a unidade técnica que assegura à gestão dos serviços de saúde relacionados ao HIV, sendo sua missão regulamentar e coordenar a prestação de cuidados e tratamento às pessoas vivend...
HIV/immunology,
HIV Testing/statistics & numerical data,
Acquired Immunodeficiency Syndrome/drug therapy,
Acquired Immunodeficiency Syndrome/prevention & control,
Sexually Transmitted Diseases/diagnosis,
Tuberculosis/diagnosis,
Sexually Transmitted Diseases/drug therapy,
Mozambique,
Sexually Transmitted Diseases/prevention & control,
Anti-Retroviral Agents/administration & dosage,
Circumcision, Male/statistics & numerical data,
Tuberculosis/drug therapy
