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A stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation

Castro, Lucia Carratala; Ssengooba, Willy; Kay, Alex; Acácio, Sozinho; Ehrlich, Joanna; DiNardo, Andrew R; Shiba, Shiba; Nsubuga, Joachim K; Munguambe, Shilzia; Cervera, Belén Saavedra; Manjate, Patricia; Mulengwa, Durbbin; Sibandze, Busizwe; Ziyane, Mangaliso; Kasule, George; Mambuque, Edson; Sekadde, Moorine Penninah; Wobudeya, Eric; Joloba, Moses L; Heyckendorf, Jan; Lange, Christoph; Hermans, Sabine; Mandalakas, Anna; Basteiro, Alberto L García; Varela, Elisa Lopez.
BMC infect. dis; 24 (1), 2024
Background: Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk of mortality, particularly in the absence of rapid diagnosis. The main challenges of diagnosing TB in these populations are due to the unspecific and paucibacillary di...
HIV Infections/complications, Mycobacterium tuberculosis, Tuberculosis/diagnosis, Tuberculosis, Pulmonary/diagnosis, HIV Infections/diagnosis, Multicenter Studies as Topic, Prospective Studies, Sensitivity and Specificity, Eswatini, Mozambique, Uganda
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