RDSM – Rede de Documentação sobre Saúde em Moçambique

Viral load assay performs comparably to early infant diagnosis assay to diagnose infants with HIV in Mozambique: a prospective observational study

Vubil, adolfo; Nhachigule, carina; Loquiha, osvaldo; Meggi, bindiya; Mabunda, nedio; Bollinger, timothy; Sacks, jilian a; Jani, llesh; Vojnov, lara.

J. int. aids soc; 23 (), 2020

Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...

HIV Infections/diagnosis, HIV Infections/virology, HIV-1/genetics, HIV-1/isolation & purification, HIV-1/physiology, Infant, Newborn, Diseases/diagnosis, Infant, Newborn, Diseases/virology, Mozambique, Sensitivity and Specificity, Prospective Studies, Viral Load/methods, Viremia/diagnosis, Viremia/virology

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Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults

During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. These changes have been shown to have a relevant role in predicting disease progression; however, the challeng...