During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. These changes have been shown to have a relevant role in predicting disease progression; however, the challeng...
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
A emergência do vírus influenza A(H1N1) pdm09 no México e EUA no princípio de 2009 e que se disseminou pelo mundo, causando considerável morbidade, com cerca de 18000 mortes, oferecendo uma oportunidade de se estudar a evolução do vírus influenza pandêmico em humano sem diversas partes do mundo....
HIV virology and pathogenetic mechanisms of
infection are continuously being investigated. A detailed understanding of HIV structure and how it
establishes infection and causes AIDS are crucial
not only to identify and develop new effective drugs
and vaccines, but also to define strategies for the labora...
Background: Resistant virus may be selected by sub-optimal control of HIV-1 replication during antiretroviral treatment. The incidence and profile of resistance in children receiving World Health Organization-recommended treatment remains to be evaluated on a large scale.
Goals: Assessment of the frequen...
