CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
BMC immunol. (Online); 52 (16), 2015
Publication year: 2015
Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system.
Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development
of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more
prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in
HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms.