Ubillos, itziar;
Kurtovic, liriye;
Agius, paulo, a;
Feng, gaoqian;
Drew, damien, r;
Sacarlal, jahit;
Aponte, john, j;
Fowkes, freya, j;
Dobaño, carlota;
Beeson, james, g.
Background: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S
confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary
immunization. Vaccine efficacy has some association with anti-CSP IgG; however, it i...
Valmaseda, aida;
Macete, eusebio;
Nhabomba, augusto;
Guinovart, caterina;
Aide, pedro;
Bardají, azucena;
Bassat, quique;
Nhampossa, tacilta;
Maculuve, sonia;
Casellas, aina;
Quintó, llorenç;
Sanz, sergi;
Jiménez, alfons;
Feng, gaoqian;
Langer, christine;
Reiling, linda;
Reddy, k, sony;
Pandey, alok;
Chitnis, chetan, e;
Chauhan, virander, s;
Aguilar, ruth;
Aponte, john, j;
Dobaño, carlota;
Beeson, james, g;
Gaur, deepak;
Menéndez, clara;
Alonso, pedro, l;
Mayor, alfredo.
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
Moncunill, Gemma;
Mpina, Maxmillian;
Nhabomba, Augusto J;
Aguilar, Ruth;
Ayestaran, Aintzane;
Sanz, Héctor;
Campo, Joseph J;
Jairoce, Chenjerai;
Barrios, Diana;
Dong, Yan;
Díez-Padrisa, Núria;
Fernandes, José F;
Abdulla, Salim;
Sacarlal, Jahit;
Williams, Nana A;
Harezlak, Jaroslaw;
Mordmüller, Benjamin;
Sacarlal, Jahit;
Agnandji, Selidji T;
Aponte, John J;
Daubenberger, Claudia;
Valim, Clarissa;
Dobaño, Carlota.
The RTS,S/AS01E malaria vaccine has moderate efficacy, lower in infants than children. Current efforts to enhance
RTS,S/AS01E efficacy would benefit from learning about the vaccine-induced immunity and identifying correlates of malaria protection, which could, for instance, inform the choice of adjuvants...
A primary concern for the RTS,S malaria vaccine candidate is duration of protection. The ongoing Phase III trial reported evidence of waning efficacy within the first year following vaccination. Multiple Phase IIb trials demonstrated early waning of efficacy. The longest duration of protection for RTS,S ...
Malaria remains one of the major health problems in Mozambique. The Ministry of Health, through its
National Malaria Control Programme, has defi ned strategies to intensify the scaling up of activities with the
objective of accelerating a reduction in the malaria burden.
The systematic evaluation of...
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Macete, Eusébio V;
Sacarlal, Jahit;
Aponte, John J;
Leach, Amanda;
Navia, Margarita M;
Milman, Jessica;
Guinovart, Caterina;
Mandomando, Inácio;
López-Púa, Yolanda;
Lievens, Marc;
Ofori, Alex Owusu;
Dubois, Marie-Claude;
Cahill, Conor P;
Koutsoukos, Marguerite;
Sillman, Marla;
Thompson, Ricardo;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
Results: Both vaccines were safe and had similar reactogenicity profiles. All subjects with paired pre and post-vaccination
samples showed a vaccine response with respect to anti-circumsporozoite (CS) antibodies irrespective of initial anti-CS
serostatus. Geometric mean titers (GMTs) were 191 EU/ml (95...
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Conhecimentos, Atitudes e Prática em Saúde,
Cuidadores/psicologia,
Atenção à Saúde/métodos,
Atenção à Saúde/organização & administração,
Testes Hematológicos/psicologia,
Imunização/psicologia,
Vacinas Antimaláricas/uso terapêutico,
Programas de Imunização/organização & administração,
Malária Falciparum/psicologia,
Aceitação pelo Paciente de Cuidados de Saúde/psicologia,
Moçambique/epidemiologia
