Ubillos, itziar;
Kurtovic, liriye;
Agius, paulo, a;
Feng, gaoqian;
Drew, damien, r;
Sacarlal, jahit;
Aponte, john, j;
Fowkes, freya, j;
Dobaño, carlota;
Beeson, james, g.
Background: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S
confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary
immunization. Vaccine efficacy has some association with anti-CSP IgG; however, it i...
Valmaseda, aida;
Macete, eusebio;
Nhabomba, augusto;
Guinovart, caterina;
Aide, pedro;
Bardají, azucena;
Bassat, quique;
Nhampossa, tacilta;
Maculuve, sonia;
Casellas, aina;
Quintó, llorenç;
Sanz, sergi;
Jiménez, alfons;
Feng, gaoqian;
Langer, christine;
Reiling, linda;
Reddy, k, sony;
Pandey, alok;
Chitnis, chetan, e;
Chauhan, virander, s;
Aguilar, ruth;
Aponte, john, j;
Dobaño, carlota;
Beeson, james, g;
Gaur, deepak;
Menéndez, clara;
Alonso, pedro, l;
Mayor, alfredo.
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
A primary concern for the RTS,S malaria vaccine candidate is duration of protection. The ongoing Phase III trial reported evidence of waning efficacy within the first year following vaccination. Multiple Phase IIb trials demonstrated early waning of efficacy. The longest duration of protection for RTS,S ...
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Conhecimentos, Atitudes e Prática em Saúde,
Cuidadores/psicologia,
Atenção à Saúde/métodos,
Atenção à Saúde/organização & administração,
Testes Hematológicos/psicologia,
Imunização/psicologia,
Vacinas Antimaláricas/uso terapêutico,
Programas de Imunização/organização & administração,
Malária Falciparum/psicologia,
Aceitação pelo Paciente de Cuidados de Saúde/psicologia,
Moçambique/epidemiologia
Enosse, Sonia;
Dobaño, Carlota;
Quelhas, Diana;
Aponte, John J;
Lievens, Marc;
Leach, Amanda;
Sacarlal, Jahit;
Greenwood, Brian;
Milman, Jessica;
Dubovsky, Filip;
Cohen, Joe;
Thompson, Ricardo;
Ballou, W Ripley;
Alonso, Pedro L;
Conway, David J;
Sutherland, Colin J.
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger th...
Alonso, pedro L;
Sacarlal, jahit;
Aponte, john J;
Leach, amanda;
Macete, eusebio;
Milman, jessica;
Mandomando, inacio;
Spiessens, Bart;
Guinovart, caterina;
Espasa, mateu;
Bassat, quique;
Aide, pedro;
Anyinam, opokua Ofori;
Navia, margarita M;
Corachan, sabine.
Background: Development of an effective malaria vaccine could greatly contribute to disease control. RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African childr...
Using a geographic information system (GIS), the microepidemiology of malaria was studied in an area of 8 square km in Matola, a densely populated periurban are of Maputo, southern Mozambique. Integrating data on the geographic location of the main mosquito breeding sites, the location and characteristic...
