Resultados: 279

Delayed diagnosis and treatment of tuberculosis in HIV+ patients in Mozambique: A cost-effectiveness analysis of screening protocols based on four symptom screening, smear microscopy, urine LAM test and Xpert MTB/RIF

PLos ONE; 13 (7), 2018
Background: Tuberculosis (TB) represents the ninth leading cause of death worldwide. In 2016 are estimated 1.3 million TB deaths among HIV negative people and an additional 374,000 deaths among HIV positive people. In 2016 are estimated 1.4 million new cases of TB in people living with HIV (PLHIV), 74% o...

Effect of point-of-care early infant diagnosis on antiretroviral therapy initiation and retention of patients

AIDS res. hum. retrovir; 32 (11), 2018
HIV/AIDS is a leading cause of infant mortality in sub-Saharan Africa. Despite significant improvements in preventing vertical transmission, in the 21 Global Plan priority countries in sub-Saharan Africa, over 100 000 infants are infected with HIV annually and only 50% access life-saving antiretroviral t...

Bisexual and Bidirectional: Assessing the Potential for HIV Bridging in Mozambique

AIDS behav; 22 (7), 2018
African men who have sex with men (MSM) frequently, and often concurrently, have female partners, raising concerns about HIV sexual bridging. We explored potential HIV transmission in Mozambique from and to female partners of MSM focusing on preferred anal sex role and circumcision status. Data collected...

Performance of point-of-care birth HIV testing in primary health care clinics: An observational cohort study

PLOS ONE; 13 (6), 2018
Worldwide only 43% of infants infected with HIV have access to antiretroviral treatment (ART). Despite significant global efforts to expand access to paediatric treatment, coverage lags behind adult ART and may not reach the 90-90-90 goals by 2020 as set by UNAIDS [2]. Resolving this paediatric ART gap i...

Optimizing the immunogenicity of HIV primeboost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

PLOS ONE; 13 (6), 2018
Although there has been a decline in the number of new human immunodeficiency virus (HIV) infections over the years, millions of people continue to be exposed and infected [1]. More than 200 HIV vaccine phase I and II, and 6 efficacy trials have been conducted [2, 3]. The RV144 Thai trial is the only tri...

Pathways of care for HIV infected children in Beira, Mozambique: pre-post intervention study to assess impact of task shifting

Background: In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was designed to evaluate effectiveness of a new pathway of care in a sample of Beira Dis...

Partners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol

Contemp. clin. trials; 71 (63), 2018
Background: In resource-limited rural settings, scale-up of services to eliminate mother-to-child transmission of HIV has not been as effective as in better resourced urban settings. In sub-Saharan Africa, women often require male partner approval to access and remain engaged in HIV care. Our study will ...

HIV drug resistance patterns in pregnant women using next generation sequence in Mozambique

PLos ONE; 13 (5), 2018
Background: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (...

Monitoring progress towards the first UNAIDS target: understanding the impact of people living with HIV who re-test during HIV-testing campaigns in rural Mozambique

J. int. aids soc; 21 (4), 2018
This analysis was nested in a prospective cohort established in southern Mozambique which conducted three HIV-testing modalities: voluntary counselling and testing (VCT), provider-initiated counselling and testing (PICT) and home-based testing (HBT). Participants were given the opportunity to self-report...

Managing Advanced HIV Disease in a Public Health Approach
Managing Advanced HIV Disease in a Public Health Approach

Clin Infect Dis; 66 (2), 2018
Em 2017, a Organização Mundial da Saúde (OMS) publicou diretrizes para o manejo da doença avançada pelo vírus da imunodeficiência humana (HIV) dentro de uma abordagem de saúde pública. Dados recentes sugerem que mais de um terço das pessoas que iniciam a terapêutica anti-retroviral (TARV) o fa...