Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger th...
Background: Development of an effective malaria vaccine could greatly contribute to disease control. RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African childr...
The leading malaria vaccine candidate, RTS,S, targets the
sporozoite and liver stages of the Plasmodium falciparum
life cycle, yet it provides partial protection against disease
associated with the subsequent blood stage of infection.
Antibodies against the vaccine target, the circumsporozoite protein, h...
Using a geographic information system (GIS), the microepidemiology of malaria was studied in an area of 8 square km in Matola, a densely populated periurban are of Maputo, southern Mozambique. Integrating data on the geographic location of the main mosquito breeding sites, the location and characteristic...
