Galatas, beatriz;
Soler, helena martí;
Nhamussua, lidia;
Cisteró, pau;
Assessor, pedro;
Menéndez, clara;
Saute, francisco;
Rabinovich, regina;
Alonso, pedro L;
Prefeito, alfredo;
Bassat, quique.
Background. Afebrile Plasmodium falciparum infections usually remain undetected and untreated in the community and could potentially contribute to sustaining local malaria transmission in areas aiming for malaria elimination. Methods. Thirty-two men with afebrile P. falciparum infections detected with ra...
Mayor, alfredo;
Dobaño, carlota;
Nhabomba, augusto;
Guinovart, caterina;
Jiménez, alfonso;
Manaca, maria nelia;
Aguilar, ruth;
Barbosa, arnoldo;
Rodríguez, mauricio H;
Cisteró, pau;
Quimice, lazaro M;
Menéndez, clara;
Aponte, john J;
Ordi, jaume;
Chitnis, chetan E;
Alonso, pedro L.
Background: Difficulties to disentangle the protective versus exposure role of anti-malarial antibodies hamper the identification of clinically-relevant immune targets. Here, factors affecting maternal IgG and IgMs against Plasmodium falciparum antigens, as well as their relationship with parasite infect...
Malária Falciparum/diagnóstico,
Moçambique,
Plasmodium falciparum/imunologia,
Anticorpos Monoclonais,
Imunoglobulina G/metabolismo,
Características da População,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle,
Complicações Parasitárias na Gravidez/diagnóstico,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/prevenção & controle,
Complicações Parasitárias na Gravidez/parasitologia,
Prevalência
Dobano, carlota;
Berthoud, tamara;
Nhabomba, augusto;
Manaca, maria nelia;
Guinovart, caterina;
Aguilar, ruth;
Barbosa, arnoldo;
Groves, penny;
Rodríguez, mauricio H;
Jimenez, alfons;
Quimice, lazaro M;
Aponte, john J;
Ordi, jaume;
Doolan, denise L;
Mayor, alfredo;
Alonso, pedro L.
Background: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to mal...
Valmaseda, aida;
Macete, eusebio;
Nhabomba, augusto;
Guinovart, caterina;
Aide, pedro;
Bardají, azucena;
Bassat, quique;
Nhampossa, tacilta;
Maculuve, sonia;
Casellas, aina;
Quintó, llorenç;
Sanz, sergi;
Jiménez, alfons;
Feng, gaoqian;
Langer, christine;
Reiling, linda;
Reddy, k, sony;
Pandey, alok;
Chitnis, chetan, e;
Chauhan, virander, s;
Aguilar, ruth;
Aponte, john, j;
Dobaño, carlota;
Beeson, james, g;
Gaur, deepak;
Menéndez, clara;
Alonso, pedro, l;
Mayor, alfredo.
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
Gupta, himanshu;
Macete, eusebio;
Bulo, helder;
Salvador, crizolgo;
Warsame, marian;
Carvalho, eva;
Ménard, didier;
Ringwald, pascal;
Bassat, quique;
Enosse, sonia;
Mayor, alfredo.
One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collect...
Gupta, himanshu;
Matambisso, gloria;
Galatas, beatriz;
Simone, wilson;
Nhamussua, lidia;
Cisteró, pau;
Cunningham, jane;
Rabinovich, N regina;
Saute, francisco;
Alonso, pedro L;
Aide, pedro;
Mayor, Alfredo.
Background: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnos tic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. Methods: Plasmodium...
Fonseca, ana maria;
Quinto, llorenç;
Jiménez, alfons;
González, raquel;
Bardají, azucena;
Maculuve, sonia;
Dobaño, carlota;
Rupérez, maria;
Vala, anifa;
Aponte, john, j;
Sevene, esperanza;
Macete, Eusebio;
Menéndez, clara;
Mayor, alfredo.
Background: Pregnant women exposed to Plasmodium falciparum generate antibodies against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes to the placenta. There is a need of high-throughput tools to determine the fine specificity of these antibodies that can be used to identif...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Antígenos de Protozoários/genética,
Antígenos de Protozoários/imunologia,
Antígenos de Protozoários/metabolismo,
Teste em Amostras de Sangue Seco,
Eritrócitos/parasitologia,
Imunoensaio,
Imunoglobulina G/sangue,
Malária Falciparum/diagnóstico,
Plasmodium falciparum/isolamento & purificação,
Gravidez
Ndam, Nicaise Tuikue;
Mbuba, Emmanuel;
Gonzalez, Raquel 5;
Cistero, Pau;
Kariuki, Simon;
Sevene, Esperança;
Ruperez, María 5 6;
Fonseca, Ana Maria 5 9;
Vala, Anifa;
Muculuve, Sonia;
Jimenez, Alfons;
Quinto, Llorenç;
Ouma, Peter;
Ramharter, Michael;
Desai, Meghna;
Macete, Eusebio;
Cot, Michel;
Menendez, Clara;
Mayor, Alfredo.
Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malari...
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimaláricos/uso terapêutico,
Artemisininas/uso terapêutico,
Malária/epidemiologia,
d0109630,
d0200660,
d0161330,
Combinação Arteméter e Lumefantrina,
Combinação de Medicamentos,
Etanolaminas/uso terapêutico,
Fluorenos/uso terapêutico,
Malária Falciparum/terapia,
Malária Falciparum/epidemiologia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/genética,
Reação em Cadeia da Polimerase,
Moçambique/epidemiologia
Galatas, beatriz;
Nhamussua, lidia;
Candrinho, baltazar;
Mabote, lurdes;
Cistero, pau;
Gupta, himanshu;
Rabinovich, regina;
Menendez, clara;
Macete, eusebio;
Saute, francisco;
Mayor, alfredo;
Alonso, pedro;
Bassat, quique;
Aide, pedro.
Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was ...
