Resultados: 34

Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women

Malar. j. (Online); 8 (9), 2009
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal. Methods: The presence of Plasmodium falciparum was assessed by real-...

Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis?

Malar. j. (Online); 7 (252), 2008
Background: The potential impact of HIV-1 on falciparum malaria has been difficult to determine because of diagnostic problems and insufficient epidemiological data. Methods: In a prospective, cross-sectional study, clinical and laboratory data was registered consecutively for all adults admitted to a me...

Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique

Malar. j. (Online); 7 (115), 2008
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...

Malaria in rural Mozambique. Part II: children admitted to hospital

Malar. j. (Online); 7 (37), 2008
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...

Malaria in rural Mozambique. Part I: children attending the outpatient clinic

Malar. j. (Online); 7 (36), 2008
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation. Methods: Retrospective analysis of data collected through the Manhiça morbidit...

Safety of the RTS, S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial
Safety of the RTS,S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial

Vaccine; 26 (2), 2008
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...

Prevalence and predictors of maternal peripheral malaria parasitemia in central Mozambique

Am. j. trop. med. hyg; 77 (2), 2007
Malaria infection during pregnancy (MiP) is heterogeneously distributed even in malaria-endemic countries. Program planners require data to facilitate identification of highest-priority populations for MiP control. Using data from two cross-sectional studies of 5,528 pregnant women in 8 neighboring sites...

AAge interactions in the development of naturally acquired immunity to plasmodium falciparum and its clinical presentation

PloS med; 4 (7), 2007
Background Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and th...

Safety and immunogenicity of the RTS, S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique

Trop. med. int. health; 29 (1), 2007
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...

Seven years of regional malaria control collaboration--Mozambique, South Africa, and Swaziland

Am. j. trop. med. hyg; 76 (1), 2007