Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malária Falciparum/epidemiologia,
Proteína 1 de Superfície de Merozoito,
Plasmodium falciparum,
Proteínas de Protozoários,
Pirimetamina,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Parasitemia/terapia,
Parasitemia/epidemiologia,
Plasmodium falciparum/efeitos dos fármacos,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Reação em Cadeia da Polimerase,
Complicações Parasitárias na Gravidez/terapia,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/parasitologia
Background: The potential impact of HIV-1 on falciparum malaria has been difficult to determine
because of diagnostic problems and insufficient epidemiological data.
Methods: In a prospective, cross-sectional study, clinical and laboratory data was registered
consecutively for all adults admitted to a me...
Infecções/complicações,
d0024870,
Infecções por HIV/mortalidade,
d0067610,
Infecções por HIV/virologia,
Malária Falciparum/epidemiologia,
d0000829220,
HIV-1/isolamento & purificação,
Hipoglicemia,
Hipotensão,
Malária Falciparum/mortalidade,
Fatores de Risco
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pirimetamina/farmacologia,
Proteínas de Protozoários/genética,
Malária Falciparum/epidemiologia,
d0161330,
d0138120,
Moçambique/epidemiologia,
Ligases,
Combinação de Medicamentos,
Resistência a Medicamentos/genética,
Combinação Ezetimiba e Simvastatina/uso terapêutico,
Pirimetamina/provisão & distribuição,
Preparações Farmacêuticas,
Haplótipos/genética,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/efeitos da radiação,
Plasmodium falciparum/isolamento & purificação,
Proteínas de Protozoários/normas,
Sulfadoxina/farmacologia
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malária Falciparum/epidemiologia,
Malária Falciparum/mortalidade,
Malária Falciparum/fisiopatologia,
Malária Falciparum/terapia,
Análise Multivariada,
Plasmodium falciparum/isolamento & purificação,
Moçambique/epidemiologia,
Modelos Logísticos,
Fatores de Risco,
Estações do Ano,
Hospitalização
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria infection during pregnancy (MiP) is heterogeneously distributed even in malaria-endemic countries. Program planners require data to facilitate identification of highest-priority populations for MiP control. Using data from two cross-sectional studies of 5,528 pregnant women in 8 neighboring sites...
Background
Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We investigated the role of age in disease incidence and th...
Fatores Etários,
Anemia,
Antígenos de Protozoários/imunologia,
Anemia/prevenção & controle,
Anemia/imunologia,
Dapsona/uso terapêutico,
Quimioterapia Combinada,
Malária Falciparum/imunologia,
Malária Falciparum/prevenção & controle,
Malária Falciparum/epidemiologia,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/efeitos dos fármacos,
Tanzânia/epidemiologia,
Pirimetamina/uso terapêutico,
Resultado do Tratamento
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Sharp, brian l;
Kleinschmidt, immo;
Streat, elisabeth;
Maharaj, rajendra;
Barnes, karen i;
Durrheim, david n;
Ridl, frances c;
Morris, natasha;
Seocharan, ishen;
Kunene, simon;
Grange, jacobus j p la;
Mthembu, jotham d;
Maartens, francois;
Martin, carrin l;
Barreto, avertino.
Cooperação Internacional,
Insetos Vetores,
Essuatíni/epidemiologia,
Pré-Escolar,
Antimaláricos/uso terapêutico,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle,
Controle de Mosquitos/métodos,
Moçambique/epidemiologia,
Plasmodium falciparum/isolamento & purificação,
Prevalência,
África do Sul/epidemiologia,
Fatores de Tempo
