Resultados: 28

Pharmacokinetics of Rifampin and Isoniazid in Tuberculosis-HIVCoinfected Patients Receiving Nevirapine- or Efavirenz-Based Antiretroviral Treatment
Pharmacokinetics of Rifampin and Isoniazid in Tuberculosis-HIVCoinfected Patients Receiving Nevirapine- or Efavirenz-Based Antiretroviral Treatment

This is a substudy of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146-CARINEMO) trial, which assessed the pharmacokinetics of rifampin or isoniazid with or without the coadm...

Assessment of the BD MGIT TBc identification test for the detection of Mycobacterium tuberculosis complex in a network of mycobacteriology laboratories

BioMed res. int. (Online); 2014 (398108), 2014
We evaluate the performance of the TBcID assay in a panel of 100 acid-fast bacilli cultures. Sixty-four isolates were TBcID positive for Mycobacterium tuberculosis complex (MTBC), whereas 36 gave negative results. These included 28 nontuberculous mycobacteria, one nonmycobacterial isolate, one M. tubercu...

Mycobacterium tuberculosis Beijing genotype is associated with HIV infection in Mozambique

PLos ONE; 7 (9), 2012
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...

MLVA based classification of Mycobacterium tuberculosis complex lineages for a robust phylogeographic snapshot of its worldwide molecular diversity

PLos ONE; 7 (9), 2012
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...

Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique

BMC microbiol; 10 (195), 2010
Background: The zoonosis bovine tuberculosis (TB) is known to be responsible for a considerable proportion of extrapulmonary TB. In Mozambique, bovine TB is a recognised problem in cattle, but little has been done to evaluate how Mycobacterium bovis has contributed to human TB. We here explore the public...

Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique

BMC microbiol; 10 (195), 2010
Background: Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of Mycobacterium tuberculosis circulating in the country are important to better understand the epidemic. This study determined the predominant s...

Genotipagem utilizando a sequencia de inserção IS6110 e "spoligotyping" de mycobacterium tuberculosis isolados de pacientes infectados pelo hiv, em moçambique, africa

A tuberculose é a principal causa de morte no mundo entre as doenças infecciosas, produzindo 2 milhões de óbitos ao ano. Estima-se que um terço da população mundial esteja infectada pelo Mycobacterium tuberculosis, ou seja, 1,7 bilhões de pessoas. Em países africanos, o problema da tuberculose e...

Genotipagem, utilizando a sequencia de inserção IS6110, de cepas de Mycobacterium tuberculosis isoladas de pacientes portadores da infecção pelo HIV em Moçambique, Africa

A técnica do estudo do polimorfismo de fragmentos de restrição, com a pesquisa da seqüência de inserção IS6110 (IS6110-RFLP), é o método de genotipagem mais empregado mundialmente para a caracterização de isolados de M. tuberculosis. Ela pode ser empregada para o estudo de surtos, epidemias ou...