Gupta, himanshu;
Matambisso, gloria;
Galatas, beatriz;
Simone, wilson;
Nhamussua, lidia;
Cisteró, pau;
Cunningham, jane;
Rabinovich, N regina;
Saute, francisco;
Alonso, pedro L;
Aide, pedro;
Mayor, Alfredo.
Background: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnos tic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. Methods: Plasmodium...
Fonseca, ana maria;
Quinto, llorenç;
Jiménez, alfons;
González, raquel;
Bardají, azucena;
Maculuve, sonia;
Dobaño, carlota;
Rupérez, maria;
Vala, anifa;
Aponte, john, j;
Sevene, esperanza;
Macete, Eusebio;
Menéndez, clara;
Mayor, alfredo.
Background: Pregnant women exposed to Plasmodium falciparum generate antibodies against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes to the placenta. There is a need of high-throughput tools to determine the fine specificity of these antibodies that can be used to identif...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Antígenos de Protozoários/genética,
Antígenos de Protozoários/imunologia,
Antígenos de Protozoários/metabolismo,
Teste em Amostras de Sangue Seco,
Eritrócitos/parasitologia,
Imunoensaio,
Imunoglobulina G/sangue,
Malária Falciparum/diagnóstico,
Plasmodium falciparum/isolamento & purificação,
Gravidez
Ndam, Nicaise Tuikue;
Mbuba, Emmanuel;
Gonzalez, Raquel 5;
Cistero, Pau;
Kariuki, Simon;
Sevene, Esperança;
Ruperez, María 5 6;
Fonseca, Ana Maria 5 9;
Vala, Anifa;
Muculuve, Sonia;
Jimenez, Alfons;
Quinto, Llorenç;
Ouma, Peter;
Ramharter, Michael;
Desai, Meghna;
Macete, Eusebio;
Cot, Michel;
Menendez, Clara;
Mayor, Alfredo.
Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malari...
Moncunill, Gemma;
Mpina, Maxmillian;
Nhabomba, Augusto J;
Aguilar, Ruth;
Ayestaran, Aintzane;
Sanz, Héctor;
Campo, Joseph J;
Jairoce, Chenjerai;
Barrios, Diana;
Dong, Yan;
Díez-Padrisa, Núria;
Fernandes, José F;
Abdulla, Salim;
Sacarlal, Jahit;
Williams, Nana A;
Harezlak, Jaroslaw;
Mordmüller, Benjamin;
Sacarlal, Jahit;
Agnandji, Selidji T;
Aponte, John J;
Daubenberger, Claudia;
Valim, Clarissa;
Dobaño, Carlota.
The RTS,S/AS01E malaria vaccine has moderate efficacy, lower in infants than children. Current efforts to enhance
RTS,S/AS01E efficacy would benefit from learning about the vaccine-induced immunity and identifying correlates of malaria protection, which could, for instance, inform the choice of adjuvants...
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimaláricos/uso terapêutico,
Artemisininas/uso terapêutico,
Malária/epidemiologia,
d0109630,
d0200660,
d0161330,
Combinação Arteméter e Lumefantrina,
Combinação de Medicamentos,
Etanolaminas/uso terapêutico,
Fluorenos/uso terapêutico,
Malária Falciparum/terapia,
Malária Falciparum/epidemiologia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/genética,
Reação em Cadeia da Polimerase,
Moçambique/epidemiologia
Galatas, beatriz;
Nhamussua, lidia;
Candrinho, baltazar;
Mabote, lurdes;
Cistero, pau;
Gupta, himanshu;
Rabinovich, regina;
Menendez, clara;
Macete, eusebio;
Saute, francisco;
Mayor, alfredo;
Alonso, pedro;
Bassat, quique;
Aide, pedro.
Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was ...
O Inquérito de Indicadores de Imunização, Malária e HIV/SIDA (IMASIDA 2015) em Moçambique foi
realizado com o objectivo de determinar a prevalência do HIV e SIDA e malária, bem como outros
indicadores de saúde da mulher e da criança no país. O inquérito fornece dados a nível nacional, provinc...
HIV/isolamento & purificação,
Teste de HIV/métodos,
Malária/diagnóstico,
Malária/prevenção & controle,
Malária Falciparum/prevenção & controle,
Malária Falciparum/tratamento farmacológico,
Terapêutica/tendências,
Inquéritos e Questionários/estatística & dados numéricos,
Moçambique/epidemiologia,
Síndrome da Imunodeficiência Adquirida/diagnóstico,
Síndrome da Imunodeficiência Adquirida/prevenção & controle,
Indicadores Básicos de Saúde,
Relatório de Pesquisa/tendências
After the decrease in clinical malaria incidence observed in Mozambique until 2009, a steady resurgence of cases per year has been reported nationally, reaching alarming levels in 2014. However, little is known about the clinical profile of the cases presented, or the possible epidemiological factors con...
Moro, Laura;
Bardaji, Azucena;
Macete, Eusebio;
Barrios, Diana;
Prieto, Diana M Morales;
Espana, Carolina;
Mandomando, Inacio;
Sigauque, Betuel;
Dobano, Carlota;
Markert, Udo R;
Ribas, Daniel Benitez;
Alonso, Pedro L;
Menendez, Clara;
Mayor, Alfredo.
During pregnancy, syncytiotrophoblast vesicles contribute to maternal tolerance towards the fetus, but also to pathologies such as pre-eclampsia. The aim of the study was to address whether Plasmodium falciparum and HIV infections in pregnancy affect the secretion, microRNA content and function of tropho...
Malária Falciparum/patologia,
Malária Falciparum/metabolismo,
Placenta/metabolismo,
Resultado da Gravidez,
Micropartículas Derivadas de Células/metabolismo,
Micropartículas Derivadas de Células/ultraestrutura,
Quimiocinas/metabolismo,
Células Dendríticas/metabolismo,
Demografia/estatística & dados numéricos,
Recém-Nascido,
MicroRNAs/metabolismo,
Plasmodium falciparum/fisiologia,
Trofoblastos/metabolismo,
Moçambique
