Serra-Casa, Elisa;
Menéndez, Clara;
Dobaño, Carlota;
Bardají, Azucena1 2;
Quintó, Llorençc;
Ordi, Jaume;
Sigauque, Betuel;
Cisteró, Pau;
Mandomando, Inácio;
Alonso, Pedro L;
Mayor, Alfredo.
Pregnant women are susceptible to Plasmodium falciparum parasites that sequester in the placenta. The massive accumulation of infected erythrocytes in the placenta has been suggested to trigger the deleterious effects of malaria in pregnant women and their offspring. The risk of malaria is also high duri...
To determine the prevalence of acute HIV infection (AHI) within the HIV-seronegative adult population presenting with reported fever in a district hospital in southern Mozambique and evaluate clinical, immunological and virological parameters of AHI.
Design:
This is a prospective observational study.
...
Background: An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique.
Methods: Between 2003 and 2005, 411 patients over one year and 10 kg with uncomplicated Plasm...
Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malária Falciparum/epidemiologia,
Proteína 1 de Superfície de Merozoito,
Plasmodium falciparum,
Proteínas de Protozoários,
Pirimetamina,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Parasitemia/terapia,
Parasitemia/epidemiologia,
Plasmodium falciparum/efeitos dos fármacos,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Reação em Cadeia da Polimerase,
Complicações Parasitárias na Gravidez/terapia,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/parasitologia
Background: The potential impact of HIV-1 on falciparum malaria has been difficult to determine
because of diagnostic problems and insufficient epidemiological data.
Methods: In a prospective, cross-sectional study, clinical and laboratory data was registered
consecutively for all adults admitted to a me...
Infecções/complicações,
d0024870,
Infecções por HIV/mortalidade,
d0067610,
Infecções por HIV/virologia,
Malária Falciparum/epidemiologia,
d0000829220,
HIV-1/isolamento & purificação,
Hipoglicemia,
Hipotensão,
Malária Falciparum/mortalidade,
Fatores de Risco
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Anticorpos Antiprotozoários/genética,
Antimaláricos/administração & dosagem,
Antimaláricos/uso terapêutico,
Malária Falciparum/imunologia,
Malária Falciparum/prevenção & controle,
Plasmodium falciparum/imunologia,
Pirimetamina/administração & dosagem,
Moçambique,
Proteínas Recombinantes/genética,
Proteínas Recombinantes/imunologia
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pirimetamina/farmacologia,
Proteínas de Protozoários/genética,
Malária Falciparum/epidemiologia,
d0161330,
d0138120,
Moçambique/epidemiologia,
Ligases,
Combinação de Medicamentos,
Resistência a Medicamentos/genética,
Combinação Ezetimiba e Simvastatina/uso terapêutico,
Pirimetamina/provisão & distribuição,
Preparações Farmacêuticas,
Haplótipos/genética,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/efeitos da radiação,
Plasmodium falciparum/isolamento & purificação,
Proteínas de Protozoários/normas,
Sulfadoxina/farmacologia
Mayor, Alfredo;
Serra-Casas, Elisa;
Sanz, Sergi;
Aponte, João J;
Machete, eusebio;
Mandomando, Inácio;
Puyol, Laura;
Berzosa, Pedro;
Dobanã, Carlota;
Aide, pedro;
Sacarlal, jahit;
Benito, Agustín;
Alonso, Pedro;
Menendéz, Clara.
Background. Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a po tential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to incr...
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malária Falciparum/epidemiologia,
Malária Falciparum/mortalidade,
Malária Falciparum/fisiopatologia,
Malária Falciparum/terapia,
Análise Multivariada,
Plasmodium falciparum/isolamento & purificação,
Moçambique/epidemiologia,
Modelos Logísticos,
Fatores de Risco,
Estações do Ano,
Hospitalização
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
