Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Sharp, brian l;
Kleinschmidt, immo;
Streat, elisabeth;
Maharaj, rajendra;
Barnes, karen i;
Durrheim, david n;
Ridl, frances c;
Morris, natasha;
Seocharan, ishen;
Kunene, simon;
Grange, jacobus j p la;
Mthembu, jotham d;
Maartens, francois;
Martin, carrin l;
Barreto, avertino.
Cooperação Internacional,
Insetos Vetores,
Essuatíni/epidemiologia,
Pré-Escolar,
Antimaláricos/uso terapêutico,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle,
Controle de Mosquitos/métodos,
Moçambique/epidemiologia,
Plasmodium falciparum/isolamento & purificação,
Prevalência,
África do Sul/epidemiologia,
Fatores de Tempo
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Conhecimentos, Atitudes e Prática em Saúde,
Cuidadores/psicologia,
Atenção à Saúde/métodos,
Atenção à Saúde/organização & administração,
Testes Hematológicos/psicologia,
Imunização/psicologia,
Vacinas Antimaláricas/uso terapêutico,
Programas de Imunização/organização & administração,
Malária Falciparum/psicologia,
Aceitação pelo Paciente de Cuidados de Saúde/psicologia,
Moçambique/epidemiologia
Enosse, Sonia;
Dobaño, Carlota;
Quelhas, Diana;
Aponte, John J;
Lievens, Marc;
Leach, Amanda;
Sacarlal, Jahit;
Greenwood, Brian;
Milman, Jessica;
Dubovsky, Filip;
Cohen, Joe;
Thompson, Ricardo;
Ballou, W Ripley;
Alonso, Pedro L;
Conway, David J;
Sutherland, Colin J.
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger th...
We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and wet se...
Malária/epidemiologia,
Malária/parasitologia,
Moçambique,
Especificidade da Espécie,
Plasmodium ovale,
Coinfecção,
Malária Falciparum/diagnóstico,
Coinfecção/transmissão,
Plasmodium falciparum/isolamento & purificação,
Plasmodium ovale/isolamento & purificação,
Reação em Cadeia da Polimerase,
Moçambique/epidemiologia
Alonso, pedro L;
Sacarlal, jahit;
Aponte, john J;
Leach, amanda;
Macete, eusebio;
Milman, jessica;
Mandomando, inacio;
Spiessens, Bart;
Guinovart, caterina;
Espasa, mateu;
Bassat, quique;
Aide, pedro;
Anyinam, opokua Ofori;
Navia, margarita M;
Corachan, sabine.
Background: Development of an effective malaria vaccine could greatly contribute to disease control. RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African childr...
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Cloroquina/efeitos adversos,
Amodiaquina/administração & dosagem,
Malária Falciparum/tratamento farmacológico,
Sulfadoxina/administração & dosagem,
Antimaláricos/administração & dosagem,
Antimaláricos/efeitos adversos,
Cloroquina/administração & dosagem,
Malária Falciparum/terapia,
Plasmodium falciparum/efeitos da radiação,
Pirimetamina/administração & dosagem,
Pirimetamina/efeitos adversos,
Resultado do Tratamento
We estimated the incidence of clinical malaria episodes by weekly home-based active case detection between December 1996 and July 1999 in 2 groups of children in Manhiça district in southern Mozambique. Cohort 1 comprised a random sample of children aged <10 years at recruitment and cohort 2 comprised n...
A total of 2057 children aged <10 years were selected at random from a demographic surveillance system and enrolled in 4 malariometric cross-sectional surveys in different seasons in Manhiça district in southern Mozambique. Plasmodium falciparum accounted for 90% of all malaria infections and the preval...
