Resultados: 15

MARVEL-minimising the emergence and dissemination of HIV-1 drug resistance in Portuguese-speaking African Countries (PALOP): low-cost portable NGS platform for HIV-1 surveillance in Africa

BMC infect. dis; 24 (1), 2024
Background HIV-1 infections remain a global public health concern. Scaled-up antiretroviral treatment (ART) is crucial for reducing morbidity and mortality related to HIV/AIDS. The emergence of drug-resistance mutations (DRMs) compromises viral suppression and contributes to the continued HIV-1 transmiss...

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Science .; 378 (), 2022
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoun...

COVID-19 imported cases and severity: expected information from genomic characterization of SARS-CoV-2 strains in Mozambique

J. infect. dev. ctries; 15 (12), 2021
Introduction: The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), etiological agent of coronavirus disease 2019 (COVID-19) was first reported in China in December 2019 and spread worldwide. As of March 6th, 2021, there have been 116,670,105 million confirmed cases globall...

Os Dilemas Bioéticos do Impacto da COVID-19 nos Sistemas de Saúde Africanos
The Bioethical Dilemmas of the Impact of COVID-19 on Systems African Health More about

A partir de uma revisão bibliográfica sobre os efeitos da pandemia da COVID-19, o artigo apresenta e analisa os dilemas bioéticos que surgem da necessidade de dedicar mais recursos sanitários ao controlo da mesma. Os esforços por controlar a propagação do SARS-CoV-2 significaram diminuição da at...

Infant vaccination against malaria in Mozambique and in Togo: mapping parents' willingness to get their children vaccinated

Background: Malaria is one of the most widespread and deadly diseases worldwide and large majority of malaria cases and deaths occurs in Africa. Efforts to develop an effective vaccine against malaria are underway and several vaccine prototypes are on different clinical trial phases.Objective: As many su...

Seroepidemiological Studies of Arboviruses in Africa

Adv. exp. med. biol; 1062 (), 2018
The literature on sero-epidemiological studies of flaviviral infections in the African continent is quite scarce. Much of the viral epidemiology studies have been focussing on diseases such as HIV/AIDS because of their sheer magnitude and impact on the lives of people in the various affected countries. I...

Cardiovascular disease in Africa: epidemiological profile and challenges

From a global perspective, the large and diverse African population is disproportionately affected by cardiovascular disease (CVD). The historical balance between communicable and noncommunicable pathways to CVD in different African regions is dependent on external factors over the life course and at a s...

HIV development assistance and adult mortality in Africa

JAMA; 16 (307), 2016
Context: The effect of global health initiatives on population health is uncertain. Between 2003 and 2008, the US President's Emergency Plan for AIDS Relief (PEPFAR), the largest initiative ever devoted to a single disease, operated intensively in 12 African focus countries. The initiative's effect on al...

Sustainable HIV Treatment in Africa through Viral Load-Informed Differentiated Care

Nature (Lond.); 528 (7580), 2015
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy (ART) in sub-Saharan Africa. Patients typically attend clinics every 1–3 months for clinical assessment, with clinic costs being comparable with costs of drugs themselves, CD4 counts are measured every 6 mon...

Perfil imunológico, virológico e expressão de CD38 pelas células TCD8 dos pacientes HIV-1 positivos e coinfectados HIV/TB seguidos no centro de Saúde da polana caniço

Segundo OMS, em 2013 aproximadamente35 milhões de pessoas no Mundo estavam infectadas pelo HIV e destes, aproximadamente 24,7milhões viviam na África Subsaariana. Em Moçambique, aprevalência é de 11,5%na população com 15-49 anos de idade. O aumento da prevalência do HIV na década de 80, provoco...