Toxoplasmosis is a parasitic zoonotic disease caused by Toxoplasma gondii that afflicts humans worldwide and wild and domestic warm-blooded animals. In immunocompetent individuals, the acute phase of infection presents transient low or mild symptoms that remain unnoticed. In immunocompromised patients, T...
Anticorpos Antiprotozoários/sangue,
Pesquisa Biomédica/tendências,
Hospedeiro Imunocomprometido,
Complicações Parasitárias na Gravidez/epidemiologia,
Toxoplasma/genética,
Imunoglobulina G/sangue,
Zoonoses/epidemiologia,
Fatores de Risco,
Moçambique/epidemiologia,
Toxoplasma/patogenicidade,
Toxoplasmose/complicações,
Toxoplasmose/epidemiologia,
Toxoplasmose Congênita/epidemiologia
Ubillos, itziar;
Kurtovic, liriye;
Agius, paulo, a;
Feng, gaoqian;
Drew, damien, r;
Sacarlal, jahit;
Aponte, john, j;
Fowkes, freya, j;
Dobaño, carlota;
Beeson, james, g.
Background: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S
confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary
immunization. Vaccine efficacy has some association with anti-CSP IgG; however, it i...
Valmaseda, aida;
Macete, eusebio;
Nhabomba, augusto;
Guinovart, caterina;
Aide, pedro;
Bardají, azucena;
Bassat, quique;
Nhampossa, tacilta;
Maculuve, sonia;
Casellas, aina;
Quintó, llorenç;
Sanz, sergi;
Jiménez, alfons;
Feng, gaoqian;
Langer, christine;
Reiling, linda;
Reddy, k, sony;
Pandey, alok;
Chitnis, chetan, e;
Chauhan, virander, s;
Aguilar, ruth;
Aponte, john, j;
Dobaño, carlota;
Beeson, james, g;
Gaur, deepak;
Menéndez, clara;
Alonso, pedro, l;
Mayor, alfredo.
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
Fonseca, ana maria;
Quinto, llorenç;
Jiménez, alfons;
González, raquel;
Bardají, azucena;
Maculuve, sonia;
Dobaño, carlota;
Rupérez, maria;
Vala, anifa;
Aponte, john, j;
Sevene, esperanza;
Macete, Eusebio;
Menéndez, clara;
Mayor, alfredo.
Background: Pregnant women exposed to Plasmodium falciparum generate antibodies against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes to the placenta. There is a need of high-throughput tools to determine the fine specificity of these antibodies that can be used to identif...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Antígenos de Protozoários/genética,
Antígenos de Protozoários/imunologia,
Antígenos de Protozoários/metabolismo,
Teste em Amostras de Sangue Seco,
Eritrócitos/parasitologia,
Imunoensaio,
Imunoglobulina G/sangue,
Malária Falciparum/diagnóstico,
Plasmodium falciparum/isolamento & purificação,
Gravidez
Mayor, Alfredo;
Bardají, Azucena;
Macete, Eusebio;
Nhampossa, Tacilta;
Fonseca, Ana Maria;
González, Raquel;
Maculuve, Sonia;
Cisteró, Pau;
Rupérez, Maria;
Campo, Joe;
Vala, Anifa;
Sigaúque, Betuel;
Jiménez, Alfons;
Machevo, Sonia;
Fuente, Laura de la;
Nhama, Abel;
Luis, Leopoldina;
Aponte, John J;
Acácio, Sozinho;
Nhacolo, Arsenio;
Chitnis, Chetan;
Dobaño, Carlota;
Sevene, Esperanza;
Alonso, Pedro Luis;
Menéndez, Clara.
Background: Prevention of reinfection and resurgence is an integral component of the goal to eradicate malaria. However, the adverse effects of malaria resurgences are not known.
Methods: We assessed the prevalence of Plasmodium falciparum infection among 1819 Mozambican women who delivered infants betwe...
Anticorpos Antiprotozoários/sangue,
Imunoglobulina G/sangue,
Malária Falciparum/classificação,
Malária Falciparum/epidemiologia,
Malária Falciparum/imunologia,
Moçambique/epidemiologia,
Carga Parasitária,
Paridade,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/isolamento & purificação,
Complicações Infecciosas na Gravidez/classificação,
Complicações Infecciosas na Gravidez/epidemiologia,
Complicações Infecciosas na Gravidez/imunologia,
Índice de Gravidade de Doença
A primary concern for the RTS,S malaria vaccine candidate is duration of protection. The ongoing Phase III trial reported evidence of waning efficacy within the first year following vaccination. Multiple Phase IIb trials demonstrated early waning of efficacy. The longest duration of protection for RTS,S ...
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Anticorpos Antiprotozoários,
d0109630,
Anticorpos Antiprotozoários/sangue,
Formação de Anticorpos/efeitos da radiação,
Antígenos de Protozoários/imunologia,
Antígenos de Superfície/imunologia,
Protocolos de Quimioterapia Combinada Antineoplásica/química,
Imunoglobulina G/sangue,
Malária Falciparum/sangue,
Malária Falciparum/imunologia,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle,
Proteínas de Membrana/imunologia,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/patogenicidade,
Proteínas de Protozoários/imunologia,
Moçambique
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Anticorpos Antiprotozoários/genética,
Antimaláricos/administração & dosagem,
Antimaláricos/uso terapêutico,
Malária Falciparum/imunologia,
Malária Falciparum/prevenção & controle,
Plasmodium falciparum/imunologia,
Pirimetamina/administração & dosagem,
Moçambique,
Proteínas Recombinantes/genética,
Proteínas Recombinantes/imunologia
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
