González, raquel;
Nhampossa, tacilta 3;
Ngoma, ghyslain mombo;
Mischlinger, johannes;
Esen, meral;
Tchouatieu, andré marie;
Duran, clara pons;
Dimessa, lia betty;
Lell, bertrand;
Lagler, heimo;
Otero, laura garcia.
Introduction: Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV-infected women. Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine is recommended for malaria prevention in HIV-uninfected women, but it is contr...
Sevene, esperança;
Banda, clifford G;
Mukaka, mavuto;
Maculuve, sonia;
Vala, anifa;
Macuacua, salésio;
Piqueras, mireia;
Phiri, linda kalilani;
Mallewa, jane;
Terlouw, dianne J;
Khoo, saye H;
Lalloo, david G;
Mwapasa, victor.
Background: HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efcacy and safety has not been ...
Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Tint, Halidou;
Seveno, Esperança;
Dellicour, Stephanie;
Calip, Gregory S;
D'Alessandro, Umberto;
Macete, Eusébio;
Diallo , Seydou Nakanabo;
Kazienga, Adama;
Valea, Innocent;
Sorgho, Hermann;
Valá, Anifa;
Augusto, Orvalho;
Ruperez, Clara;
Menendez, Clara;
Ouma, Peter;
Desai, Meghna;
Kuile, Feiko Ter;
Stergachis, Andy.
Background: A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in the first trimester of pregnancy. There is a need for human data to inform policy makers and treatment guidelines on the safety of artemisinin combination therapies (ACT) wh...
Antimaláricos/efeitos adversos,
Artemisininas/efeitos adversos,
Protocolos Clínicos,
Estudos de Coortes,
Esquema de Medicação,
Idade Gestacional,
Malária/terapia,
Troca Materno-Fetal,
Seleção de Pacientes,
Farmacovigilância,
Complicações Parasitárias na Gravidez/terapia,
Resultado da Gravidez,
Primeiro Trimestre da Gravidez,
Efeitos Tardios da Exposição Pré-Natal,
Estudos Prospectivos,
Projetos de Pesquisa,
Tamanho da Amostra,
Moçambique,
Burkina Faso,
Quênia,
Antimaláricos/uso terapêutico,
Artemisininas/uso terapêutico
Baiden, Rita;
Oduro, Abraham;
Halidou, Tinto;
Gyapong, Margaret;
Sie, Ali;
Macete, Eusebio;
Abdulla, Salim;
Agyei, Seth Owusu;
Mulokozi, Abdunoor;
Adjei , Alex 10;
Sevene, Esperanca;
Compaore, Guillaume;
Valea, Innocent;
Osei, Isaac;
Yawson, Abena;
Adjuik, Martin;
Akparibo, Raymond;
Ogutu, Bernhards;
Upunda, Gabriel Leonard;
Smith, Peter;
Binka, Fred.
Background: The World Health Organization recommends artemisinin-based combination (ACT) for the treatment of uncomplicated malaria. Post-licensure safety data on newly registered ACT is critical for evaluating their risk/benefit profile in malaria endemic countries. The clinical safety of the newly regi...
Nhama, Abel;
Bassat 1, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre...
Amodiaquina/uso terapêutico,
Antimaláricos/efeitos adversos,
Antimaláricos/uso terapêutico,
Combinação Arteméter e Lumefantrina,
Artemisininas/efeitos adversos,
Artemisininas/uso terapêutico,
Combinação de Medicamentos,
Etanolaminas/efeitos adversos,
Etanolaminas/uso terapêutico,
Artesunato/uso terapêutico,
Fluorenos/uso terapêutico,
Malária Falciparum/tratamento farmacológico,
Malária Falciparum/epidemiologia,
Combinação Arteméter e Lumefantrina/uso terapêutico,
Moçambique/epidemiologia
Nhama, Abel;
Bassat, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentr...
Amodiaquina/efeitos adversos,
Amodiaquina/uso terapêutico,
Antimaláricos/efeitos adversos,
Antimaláricos/uso terapêutico,
Combinação Arteméter e Lumefantrina,
Artemisininas/efeitos adversos,
Artemisininas/uso terapêutico,
Combinação de Medicamentos,
Etanolaminas/efeitos adversos,
Etanolaminas/uso terapêutico,
Fluorenos/efeitos adversos,
Fluorenos/uso terapêutico,
Estimativa de Kaplan-Meier,
Malária Falciparum/tratamento farmacológico,
Malária Falciparum/epidemiologia,
Resultado do Tratamento,
Moçambique/epidemiologia
: There is limited data available regarding safety profile of artemisinins in early pregnancy. They are,
therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated
embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant w...
Background: The roll out of various public health programmes involving mass administration of medicines calls for the deployment of responsive pharmacovigilance systems to permit identification of signals of rare or even common adverse reactions. In developing countries in Africa, these systems are mostl...
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Cloroquina/efeitos adversos,
Amodiaquina/administração & dosagem,
Malária Falciparum/tratamento farmacológico,
Sulfadoxina/administração & dosagem,
Antimaláricos/administração & dosagem,
Antimaláricos/efeitos adversos,
Cloroquina/administração & dosagem,
Malária Falciparum/terapia,
Plasmodium falciparum/efeitos da radiação,
Pirimetamina/administração & dosagem,
Pirimetamina/efeitos adversos,
Resultado do Tratamento
