Barilar, ivan;
Fernando, Tatiana;
Utpatel, christian;
Abujate, cláudio;
Madeira, Carla, M;
José, benedita;
Mutaquiha, claudia;
Kranzer, katharina;
Niemann, tanja.
Background
In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Azam, khalide;
Khosa, celso;
Viegas, sofia;
Massango, isabel;
Bhatt, nilesh;
Jani, ilesh;
Heinrich, Norbert;
Hoelscher, michael;
Gillespie, Stephen, H.
Background: Tuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid and quantitative biomarkers to monitor treatment response are urgently needed for individual patient management and clinical trials. C-reactive protein (CRP) is oft...
Balate, dionísia alfredo;
Manhiça, ivan;
Macuacua, bachir;
José, benedita;
Banze, denise;
Langa, josé carlos;
Baltazar, cynthia semá;
Sacarlal, jahit;
Rossetto, erika valeska;
Khosa, celso.
Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases in 2017. The aim of this study was to assess the surveillance system for multidrug-resist...
Rachow, andrea;
Ivanova, olena;
Wallis, robert;
Charalambous, Salome;
Jani, ilesh;
Bhatt, Nilesh;
Kampmann, beate;
Sutherland, Jayne;
Ntinginya, Nyanda, E;
Evans, Denise;
Lönnroth, knut;
Niemann, Stefan.
Background: Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-eco...
Antituberculosos/uso terapêutico,
Incidência,
Tuberculose Pulmonar,
Patogenesia Homeopática,
Fatores de Risco,
Qualidade de Vida,
Testes de Função Respiratória,
Resultado do Tratamento,
Tuberculose Resistente a Múltiplos Medicamentos/terapia,
Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia,
Tuberculose Resistente a Múltiplos Medicamentos/fisiopatologia,
Tuberculose Pulmonar/terapia,
Tuberculose Pulmonar/epidemiologia,
Tuberculose Pulmonar/fisiopatologia
Floridia, Marco;
Ciccacci, Fausto;
Andreotti, Mauro;
Hassane, Archa;
Sidumo, Zita;
Magid, Nurja A;
Sotomane, Horacio;
David, Muhlavasse;
Mutemba, Elsa;
Cebola, Junia;
Mugunhe, Remigio José;
Riccardi, Fabio;
Marazzi, Maria Cristina;
Giuliano, Marina;
Palombi, Leonardo;
Mancinelli, Sandro.
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human
immunodeficiency virus (HIV)–positive patients are urgently needed.
Methods. At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tubercu...
Algoritmos,
Terapia Antirretroviral de Alta Atividade,
Antituberculosos,
Infecções por HIV/tratamento farmacológico,
Lipopolissacarídeos,
Técnicas de Diagnóstico Molecular,
Moçambique,
Mycobacterium tuberculosis,
Prevalência,
Sensibilidade e Especificidade,
Tuberculose Pulmonar/diagnóstico,
Escarro
Studies have been conducted in developing countries using SMS to communicate with patients to reduce the number of missed appointments and improve retention in treatment, however; very few have been scaled up. One possible reason for this could be that patients or staff are dissatisfied with the method i...
Moçambique/epidemiologia,
Antirretrovirais/uso terapêutico,
Antituberculosos/uso terapêutico,
Infecções por HIV/terapia,
Infecções por HIV/epidemiologia,
Sistemas de Alerta,
Telemedicina/métodos,
Envio de Mensagens de Texto,
HIV,
Educação em Saúde,
Comunicação,
Aprovisionamento
Background: Genotypic molecular testing may be very helpful for tuberculosis (TB) drug-resistance surveillance and for treatment guidance in low resource settings.
Methods: Descriptive analysis of M. tuberculosis isolates from Beira Central Hospital, Mozambique, during 2014-2015. Genotype MTBDRplus and ...
Objectives: We describe nevirapine and efavirenz exposure on and off tuberculosis treatment and consequences for virological efficacy and tolerance in patients included in the ANRS 12146/12214-CARINEMO trial.
Methods: Participants were randomly selected to receive either nevirapine at 200 mg twice daily...
Alcinos,
Terapia Antirretroviral de Alta Atividade/métodos,
Antituberculosos/uso terapêutico,
Benzoxazinas/uso terapêutico,
Ciclopropanos,
Infecções por HIV/terapia,
Tolerância a Medicamentos,
Fármacos Anti-HIV/uso terapêutico,
Infecções/complicações,
Nevirapina/uso terapêutico,
Tuberculose/terapia,
Tuberculose/complicações,
Resultado do Tratamento,
Moçambique
This is a substudy of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146-CARINEMO) trial, which assessed the pharmacokinetics of rifampin or isoniazid with or without the coadm...
HIV/efeitos dos fármacos,
Antituberculosos/administração & dosagem,
Benzoxazinas,
Mycobacterium,
Mycobacterium tuberculosis/efeitos dos fármacos,
Tuberculose/tratamento farmacológico,
Síndrome da Imunodeficiência Adquirida/epidemiologia,
Soroprevalência de HIV/tendências,
Hepatite/diagnóstico,
Antígenos CD4/efeitos dos fármacos,
Moçambique/epidemiologia
A Tuberculose (TB) é uma das mais antigas doenças da humanidade e constitui um sério
problema de saúde pública a nível mundial.
O fenómeno da resistência aos medicamentos da tuberculose surgiu logo após a utilização
dos primeiros tuberculostáticos para o tratamento desta doença. A resistênc...
