Barilar, ivan;
Fernando, Tatiana;
Utpatel, christian;
Abujate, cláudio;
Madeira, Carla, M;
José, benedita;
Mutaquiha, claudia;
Kranzer, katharina;
Niemann, tanja.
Background
In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Azam, khalide;
Khosa, celso;
Viegas, sofia;
Massango, isabel;
Bhatt, nilesh;
Jani, ilesh;
Heinrich, Norbert;
Hoelscher, michael;
Gillespie, Stephen, H.
Background: Tuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid and quantitative biomarkers to monitor treatment response are urgently needed for individual patient management and clinical trials. C-reactive protein (CRP) is oft...
Balate, dionísia alfredo;
Manhiça, ivan;
Macuacua, bachir;
José, benedita;
Banze, denise;
Langa, josé carlos;
Baltazar, cynthia semá;
Sacarlal, jahit;
Rossetto, erika valeska;
Khosa, celso.
Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases in 2017. The aim of this study was to assess the surveillance system for multidrug-resist...
Martin-Hughes, Rowan;
Vu, Lung;
Cheikh, Nejma;
Kelly, Sherrie L;
Hur, Nicole Fraser;
Shubber, Zara;
Manhiça, Ivan;
Mbendera, Kuzani;
Girma, Belaineh;
Pambudi, mran;
Ríos, Julia;
Elmira, Abdrahmanova;
Harimurti, Pandu;
Hafez, Reem;
Garcia, Jaime Nicolas Bayona;
Palmer, Tom;
Roberts, Anna;
Gorgens, Marelize;
Wilson, David.
Initial global-level estimates reported in June 2020 by the World Health Organization suggested that levels of disruption to TB service delivery could be as high as 25%-50% and result in an additional 6·3 million cases of tuberculosis (TB) and an additional 1·4 million TB-related deaths attributable to...
Rachow, andrea;
Ivanova, olena;
Wallis, robert;
Charalambous, Salome;
Jani, ilesh;
Bhatt, Nilesh;
Kampmann, beate;
Sutherland, Jayne;
Ntinginya, Nyanda, E;
Evans, Denise;
Lönnroth, knut;
Niemann, Stefan.
Background: Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-eco...
Antituberculosos/uso terapêutico,
Incidência,
Tuberculose Pulmonar,
Patogenesia Homeopática,
Fatores de Risco,
Qualidade de Vida,
Testes de Função Respiratória,
Resultado do Tratamento,
Tuberculose Resistente a Múltiplos Medicamentos/terapia,
Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia,
Tuberculose Resistente a Múltiplos Medicamentos/fisiopatologia,
Tuberculose Pulmonar/terapia,
Tuberculose Pulmonar/epidemiologia,
Tuberculose Pulmonar/fisiopatologia
Studies have been conducted in developing countries using SMS to communicate with patients to reduce the number of missed appointments and improve retention in treatment, however; very few have been scaled up. One possible reason for this could be that patients or staff are dissatisfied with the method i...
Moçambique/epidemiologia,
Antirretrovirais/uso terapêutico,
Antituberculosos/uso terapêutico,
Infecções por HIV/terapia,
Infecções por HIV/epidemiologia,
Sistemas de Alerta,
Telemedicina/métodos,
Envio de Mensagens de Texto,
HIV,
Educação em Saúde,
Comunicação,
Aprovisionamento
Background: Genotypic molecular testing may be very helpful for tuberculosis (TB) drug-resistance surveillance and for treatment guidance in low resource settings.
Methods: Descriptive analysis of M. tuberculosis isolates from Beira Central Hospital, Mozambique, during 2014-2015. Genotype MTBDRplus and ...
Background: Depending on the presence of mutations that determine isoniazid (INH) susceptibility (katG and inhA), Mycobacterium tuberculosis may be susceptible to high doses of INH or ethionamide (ETH).
Objective: To describe the INH resistance profile and association of katG mutation with previous INH ...
Objectives: We describe nevirapine and efavirenz exposure on and off tuberculosis treatment and consequences for virological efficacy and tolerance in patients included in the ANRS 12146/12214-CARINEMO trial.
Methods: Participants were randomly selected to receive either nevirapine at 200 mg twice daily...
Alcinos,
Terapia Antirretroviral de Alta Atividade/métodos,
Antituberculosos/uso terapêutico,
Benzoxazinas/uso terapêutico,
Ciclopropanos,
Infecções por HIV/terapia,
Tolerância a Medicamentos,
Fármacos Anti-HIV/uso terapêutico,
Infecções/complicações,
Nevirapina/uso terapêutico,
Tuberculose/terapia,
Tuberculose/complicações,
Resultado do Tratamento,
Moçambique
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at full dose) with an ef...
Infecções Oportunistas Relacionadas com a AIDS/terapia,
Fármacos Anti-HIV/administração & dosagem,
Fármacos Anti-HIV/uso terapêutico,
Fármacos Anti-HIV/efeitos da radiação,
Antituberculosos/uso terapêutico,
Benzoxazinas/uso terapêutico,
Benzoxazinas/administração & dosagem,
Benzoxazinas/efeitos adversos,
Coinfecção,
Ciclopropanos,
Interações Medicamentosas,
Quimioterapia Combinada,
Infecções por HIV/terapia,
Nevirapina/uso terapêutico,
Nevirapina/efeitos adversos,
Nevirapina/administração & dosagem,
Resultado do Tratamento,
Tuberculose/complicações,
Tuberculose/terapia,
Tuberculose Pulmonar/complicações,
Tuberculose Pulmonar/terapia,
Moçambique/epidemiologia
