Djimde, Moussa;
Tshiongo, Japhet Kabalu;
Muhindo, Hypolite Mavoko;
Tinto, Halidou;
Sevene, Esperança;
Traore, aminata;
Vala, Anifa;
Macuacua, Salesio;
Kabore, Berenger;
Dabira, Edgard Diniba;
Erhart, Annette;
Diakite, Hamadoun;
Keita, Mohamed;
Piqueras, Mireia;
González, Raquel;
Menendez, clara;
Dorlo, Thomas Pc;
Sagara, Issaka;
Mens, Petra;
Schallig, Henk;
D'Alessandro, Umberto;
Kayentao, Kassoum.
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malária Falciparum/terapia,
Artemisininas/efeitos da radiação,
Combinação Arteméter e Lumefantrina,
Ensaios Clínicos Controlados Aleatórios como Assunto,
Gestantes,
Controle de Infecções,
Parasitologia,
População da África Subsaariana,
Artemeter/uso terapêutico,
Antimaláricos/efeitos da radiação,
Moçambique/epidemiologia
Background: The entire population of Mozambique is at risk for malaria, which remains one of the leading causes of death. The 2017-2022 National Malaria Strategic Plan focuses on reducing malaria morbidity and mortality in high- and low-transmission areas. This study aimed to estimate the costs and healt...
González, raquel;
Nhampossa, tacilta 3;
Ngoma, ghyslain mombo;
Mischlinger, johannes;
Esen, meral;
Tchouatieu, andré marie;
Duran, clara pons;
Dimessa, lia betty;
Lell, bertrand;
Lagler, heimo;
Otero, laura garcia.
Introduction: Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV-infected women. Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine is recommended for malaria prevention in HIV-uninfected women, but it is contr...
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimaláricos/farmacologia,
Antimaláricos/uso terapêutico,
Artemisininas/farmacologia,
Artemisininas/uso terapêutico,
Resistência a Medicamentos/genética,
Quimioterapia Combinada,
Marcadores Genéticos,
Plasmodium falciparum/efeitos da radiação,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Polimorfismo Genético/genética,
Moçambique
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimaláricos/administração & dosagem,
Antimaláricos/farmacologia,
Antimaláricos/uso terapêutico,
Artemisininas/administração & dosagem,
Artemisininas/farmacologia,
Artemisininas/uso terapêutico,
Protocolos de Quimioterapia Combinada Antineoplásica,
Resistência a Medicamentos/genética,
Malária/parasitologia,
Malária/prevenção & controle,
Moçambique,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/genética,
Plasmodium falciparum/patogenicidade,
Polimorfismo Genético,
Proteínas de Protozoários/genética,
Proteínas de Protozoários/metabolismo,
Quinolinas/administração & dosagem,
Quinolinas/uso terapêutico,
Quinolinas/farmacologia
Orvalho, Augusto;
Stergachis, Andy;
Dellicour, Stephanie;
Tinto, Halidou;
Valá, Anifa;
Ruperez, Maria;
Macete, Eusébio;
Nakanabo-Diallo, Seydou;
Kazienga, Adama;
Valéa, Innocent;
d'Alessandro, Umberto;
Kuile, Feiko O Ter;
S Calip, Gregory;
Ouma, peter;
Desai, Meghna;
Sevene, Esperança.
While there is increasing evidence on the safety of artemisinin-based combination therapy (ACT) for the case management of malaria in early pregnancy, little is known about the association between exposure to ACT during the first trimester and the effect on fetal growth. Data were analysed from prospecti...
Sevene, esperança;
Banda, clifford G;
Mukaka, mavuto;
Maculuve, sonia;
Vala, anifa;
Macuacua, salésio;
Piqueras, mireia;
Phiri, linda kalilani;
Mallewa, jane;
Terlouw, dianne J;
Khoo, saye H;
Lalloo, david G;
Mwapasa, victor.
Background: HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efcacy and safety has not been ...
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimaláricos/uso terapêutico,
Artemisininas/uso terapêutico,
Malária/epidemiologia,
d0109630,
d0200660,
d0161330,
Combinação Arteméter e Lumefantrina,
Combinação de Medicamentos,
Etanolaminas/uso terapêutico,
Fluorenos/uso terapêutico,
Malária Falciparum/terapia,
Malária Falciparum/epidemiologia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/genética,
Reação em Cadeia da Polimerase,
Moçambique/epidemiologia
Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Adjei, aexander;
Bana, solomon narh;
Amu, alberta;
Kukula, vida;
Nagai, richard afedi;
Agyei, seth owusu;
Oduro, abraham;
Macete, Eusebio;
Abdulla, salim;
Halidou, tinto;
Sie, ali;
Osei, isaac;
Sevene, esperance;
Asante, kwaku-poku;
Mulokozi, abdunoor;
Compaore, guillaume;
Valea, innocent;
Adjuik, martin;
Baiden, rita;
Ogutu, Bernhards;
Binka, fred;
Gyapong, margaret.
Background: Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment pro...
