RDSM – Rede de Documentação sobre Saúde em Moçambique

Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses

Chissumba, Raquel Matavele; Luciano, Abílio; Namalango, Eduardo; Bauer, Asli; Bhatt, Nilesh; Wharen, Britta; Nilsson, Charlotta; Geldmacher, Christof; Scarlatti, Gabriella; Jani, Ilesh; Kastens, Luc.

Immunobiol., Suppl; 223 (12), 2018

Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...

Vacinas contra a AIDS/imunologia, Anticorpos Neutralizantes/imunologia, Contagem de Linfócito CD4, Citocinas/biossíntese, Anticorpos Anti-HIV/imunologia, Infecções por HIV/prevenção & controle, Infecções por HIV/virologia, HIV-1/imunologia, HIV-1/genética, Moçambique, Linfócitos T CD8-Positivos/imunologia, Linfócitos T Reguladores/metabolismo, Vacinas de DNA/imunologia, Vacinas de DNA/genética

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HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells recruitment into Central Nervous System

Virol. j; 165 (12), 2015

Abstract Background: The mechanisms through which HTLV-1 leads to and maintains damage in the central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) are still poorly understood. In recent years, increasing evidence indicates that, not only lympho...