Carlucci, james;
Schacht, caroline de;
Graves, erin;
González, purificación;
Bravo, magdalena;
Yu , zhihong;
Amorim , gustavo;
Arinze, folasade;
Silva, wilson;
Tique, jose a;
Alvim, maria;
Simione, beatriz;
Fernando, anibal n;
Wester, c william.
Background: Historically, antiretroviral therapy (ART) initiation was based on CD4 criteria, but this has been replaced with "Test and Start" wherein all people living with HIV are offered ART. We describe the baseline immunologic status among children relative to evolving ART policies in Mozambique.
Me...
Background: There has been tremendous progress in the fight against HIV worldwide; however, challenges persist in the control of HIV infection. These challenges include the high prevalence of late presenters. There are many disadvantages of late presentation-from reduced survival of the infected person t...
Lamp, Katherine;
McGovern , Seth;
Fong, Youyi;
Atem, Charles Diko;
Nfetam, Jean Bosco Elat;
Nzuobontane 3, Divine;
Bollinger, Timothy;
Jani 6, Ilesh;
Sitoe, Nadia;
Kiyaga 7, Charles;
Senyama, George;
Mangwendeza, Phibeon M;
Zinyowera, Sekesai Mtapuri;
Doi, Naoko;
Peter, Trevor;
Sacks, Jilian A;
Vojnov, Lara.
Background: Globally, nearly 22 million HIV-infected patients are currently accessing antiretroviral treatment; however, almost one million people living with HIV died of AIDS-related illnesses in 2018. Advanced HIV disease remains a significant issue to curb HIV-related mortality.
Methods: We analyzed 8...
Uganda,
Atenção Primária à Saúde,
Humanos,
Infecções por HIV,
Coleta de Dados,
Camarões,
Contagem de Linfócito CD4,
Instituições de Assistência Ambulatorial,
África Subsaariana/epidemiologia,
Epidemiologia,
Moçambique/epidemiologia
Fernández-Luis, Sheila;
Nhampossa, Tacilta;
Fuente-Soro, Laura;
Augusto, Orvalho;
Casellas, Aina;
Bernardo, Edson;
Ruperez, Maria;
Gonzalez, Raquel;
Maculuve, Sonia;
Saura-Lázaro, Anna;
Menendez, Clara;
Naniche, Denise;
Lopez-Varela, Elisa.
Background: There are 170,000 children living with HIV in 2017 in Mozambique. Scaling-up HIV care requires effective retention along the cascade. We sought to evaluate the pediatric cascade in HIV care at the Manhiça District Hospital. Methods: A prospective cohort of children <15 years was followed fro...
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
Vacinas contra a AIDS/imunologia,
Anticorpos Neutralizantes/imunologia,
Contagem de Linfócito CD4,
Citocinas/biossíntese,
Anticorpos Anti-HIV/imunologia,
Infecções por HIV/prevenção & controle,
Infecções por HIV/virologia,
HIV-1/imunologia,
HIV-1/genética,
Moçambique,
Linfócitos T CD8-Positivos/imunologia,
Linfócitos T Reguladores/metabolismo,
Vacinas de DNA/imunologia,
Vacinas de DNA/genética
Retention in anti-retroviral therapy (ART) presents a challenge in sub-Saharan Africa. In
Mozambique, after roll-out to peripheral facilities, the 12-month retention rate was reported
mostly from sites with an electronic patient tracking system (EPTS), representing only 65%
of patients. We conducted a na...
Fármacos Anti-HIV/farmacologia,
Contagem de Linfócito CD4,
Morte,
Perda de Seguimento,
Sistemas de Identificação de Pacientes,
HIV,
Adolescente,
Moçambique/epidemiologia,
Teste de HIV,
Antirretrovirais/uso terapêutico,
HIV/efeitos dos fármacos,
Gravidez
Marotta, Claudia;
Giaquinto, Carlo;
i Gennaro, Francesco;
Chhaganlal, Kajal D;
Saracino, Annalisa;
Moiane, Jorge;
aringhini, Guido;
Pizzol, Damiano;
Putoto, Giovanni;
Monno, Laura;
Casuccio, Alessandra;
Vitale, Francesco;
Mazzucco, Walter.
Background: In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child
nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was
designed to evaluate effectiveness of a new pathway of care in a sample of Beira Dis...
Rupérez, María;
Julian, Marc Noguera;
González, Raquel;
Maculuve, Sonia;
Bellido, Rocío;
Vala, Anifa;
Rodríguez, Cristina;
Sevene, Esperança;
Paredes, Roger;
Menéndez, Clara.
Background: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (...
During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. These changes have been shown to have a relevant role in predicting disease progression; however, the challeng...
Biomarcadores,
Células,
Citocinas,
Progressão da Doença,
Citometria de Fluxo,
HIV,
Sistema Imunitário,
Imunofenotipagem,
Imunossenescência,
Plasma,
Antígenos CD8,
Viremia,
Replicação Viral,
Contagem de Linfócito CD4
Auld, Andrew F;
Shiraishi, Ray W;
Oboho, Ikwo;
Ross, Christine;
Bateganya, Moses;
Pelletier, Valerie;
Francois, Kesner;
Delcher, Chris;
Desforges, Gracia;
Griswold, Mark;
Domercant, Jean Wysler;
Joseph, Nadjy;
Deyde, Varough;
Desir, Yrvel;
Chun, Helen;
Zulu, Isaac;
Pathmanathan, Ishani;
Robin, Ermane;
Gudo, Eduardo Samo.
Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/μL) among persons starting antiretroviral therapy (ART) is important to understand ART program outcomes, inform HIV prevention strategy, and forecast need for adjunctive therapies.*,†,§ To...
