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Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

Viegas, Edna O; Arne, Kroidl; Munseri, Patricia J; Missanga, Marco; Nilsson, Charlotta; Tembe, Nelson; Bauer, Asli; Joachin, Agricola; Joseph, Sarah; Mann, Philipp; Geldmacher, Christof; Fleck, Sue; Stöhr, Wolfgang; Scarlatti, Gabriella; Aboud, Said; Bakari, Muhammad; Maboko, Leonard; Hoelscher, Michael; Wahren, Britta; Robb, Merlin L; Weber, Jonathan; McCormack, Sheena; Biberfeld, Gunnel; Jani, Ilesh V; Sandström, Eric; Lyamuya, Eligius.
PLos ONE; 13 (11), 2018
Background: We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuva...
Adulto Jovem, Vacinas Virais, Alergia e Imunologia, Genética, Vacinas de DNA, Vacinação, Tanzânia/epidemiologia, Moçambique/epidemiologia, Humanos, Voluntários Saudáveis, Eletroporação, Anticorpos Neutralizantes, Adulto, Administração Cutânea, Vacinas contra a AIDS
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