Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors
Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: implications for integrase inhibitors
AIDS res. hum. retrovir; 28 (12), 2012
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important arget antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy andelvitegravir is in the late phase of clinical development; both show good results in monot...
DNA Viral/química, DNA Viral/genética, Farmacorresistência Viral, Variação Genética, Infecções por HIV/virologia, Integrase de HIV/genética, Inibidores de Integrase de HIV/uso terapêutico, Dados de Sequência Molecular, Provírus/genética, Mutação de Sentido Incorreto, Moçambique/epidemiologia, Análise de Sequência de DNA/instrumentação