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A Balanced Proinflammatory and Regulatory Cytokine Signature in Young African Children Is Associated With Lower Risk of Clinical Malaria

Dobaño, Carlota; Quintó, Llorenç; Barbosa, Arnoldo; Rodríguez, Mauricio H; Jiménez, Alfons; Groves, Penny L; Santano, Rebeca; Bassat, Quique 124; Aponte, John J; Guinovart, Caterina; Doolan, Denise L; Alonso, Pedro L 123.
Clin. infect. dis; 69 (Sep.2019), 2019
The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well established. As part of a double-blind, randomized, placebo-contr...
Citocinas, Leucócitos Mononucleares, Malária Falciparum, Moçambique/epidemiologia, Malária/parasitologia
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High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection

Dobano, carlota; Berthoud, tamara; Nhabomba, augusto; Manaca, maria nelia; Guinovart, caterina; Aguilar, ruth; Barbosa, arnoldo; Groves, penny; Rodríguez, mauricio H; Jimenez, alfons; Quimice, lazaro M; Aponte, john J; Ordi, jaume; Doolan, denise L; Mayor, alfredo; Alonso, pedro L.
Malar. j. (Online); 17 (1), 2018
Background: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to mal...
Malária Falciparum, Leucócitos Mononucleares, Parasitologia, Moçambique
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