Fombah, augustin E;
Chen, haily;
Quinto, llorenç;
Kyei, kwabena owusu;
Gonzalez, raquel;
Williams, julian;
Berne, mireia lLach;
Wassenaar, myrte;
Jalloh, abubakarr;
Sunders, joe-henry C;
Ramirez, maximo;
Cobo, cesc bertran;
Saute, francisco;
Ekouevi, didier K;
Briand, valérie;
Kamara, anitta R Y;
Sesay, tom;
Samai, mohamed;
Menendez, clara.
Background: Intermittent Preventive Treatment of malaria in infants (IPTi) is a malaria control strategy consisting of the administration of an anti-malarial drug alongside routine immunizations. So far, this is being implemented nationwide in Sierra Leone only. IPTi has been renamed as Perennial Malaria...
Arnaldo , Paulo;
Vallbona, Eduard Rovira;
Langa, Jerónimo S;
Salvador, Crizolgo;
Guetens, Pieter;
Chiheb, Driss;
Xavier , Bernardete;
Kestens, Luc;
Enosse, Sónia M;
Urgell , Anna Rosanas.
Malaria in pregnancy leads to serious adverse effects on the mother and the child and accounts for 75,000-200,000 infant deaths every year. Currently, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) at each sche...
Pirimetamina/administração & dosagem,
Sulfadoxina/administração & dosagem,
Antimaláricos/uso terapêutico,
d0082880,
d0149300,
d0149440,
d0090350,
Antimaláricos/administração & dosagem,
Preparações Farmacêuticas,
Instalações de Saúde,
Combinação de Medicamentos,
Trabalho de Parto/efeitos da radiação,
Complicações Parasitárias na Gravidez,
Moçambique,
Fatores de Risco,
Malária/prevenção & controle
Nhabomba, augusto J;
Guinovart, caterina;
Dobaño, carlota;
Alonso, pedro L;
Chitnis, chetan E;
Mayor, alfredo;
Aponte, john J;
Bassat, quique;
Rodríguez, mauricio H;
Barbosa, arnoldo;
Aguila, ruth;
Cisteró, pau;
Quintó, llorenç;
Manaca, maria N;
Jiménez, alfons.
Background: The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has proven difficult to elucidate. A randomized, double-blind, placebo-controlled trial using monthly chemoprophylaxis with sulphadoxine-...
Malária Falciparum/imunologia,
Moçambique/epidemiologia,
Pirimetamina/uso terapêutico,
Sulfadoxina/uso terapêutico,
Imunidade Adaptativa,
Antígenos de Protozoários/imunologia,
Exposição Ambiental,
Malária Falciparum/prevenção & controle,
Malária Falciparum/epidemiologia,
Malária Falciparum/parasitologia,
Ensaio de Imunoadsorção Enzimática,
Eritrócitos/parasitologia,
Eritrócitos/imunologia,
Quimioprevenção
Hutton, guy;
Schellenberg, david;
Tediosi, fabrizio;
Macete, eusebio;
Kahigwa, elizeus;
Sigauque, betuel;
Mas, xavier;
Trapero, marta;
Tanner, marcel;
Menendez, clara;
Alonso, pedro;
Trilla, antoni.
Objective: To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP). Methods: In two previous IPTi trials in Ifakara (United Republic of Tanzania) and Manhiça (Mozambique), SP was administered three times to infants before 9 m...
Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malária Falciparum/epidemiologia,
Proteína 1 de Superfície de Merozoito,
Plasmodium falciparum,
Proteínas de Protozoários,
Pirimetamina,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Parasitemia/terapia,
Parasitemia/epidemiologia,
Plasmodium falciparum/efeitos dos fármacos,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Reação em Cadeia da Polimerase,
Complicações Parasitárias na Gravidez/terapia,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/parasitologia
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Anticorpos Antiprotozoários/sangue,
Anticorpos Antiprotozoários/imunologia,
Anticorpos Antiprotozoários/genética,
Antimaláricos/administração & dosagem,
Antimaláricos/uso terapêutico,
Malária Falciparum/imunologia,
Malária Falciparum/prevenção & controle,
Plasmodium falciparum/imunologia,
Pirimetamina/administração & dosagem,
Moçambique,
Proteínas Recombinantes/genética,
Proteínas Recombinantes/imunologia
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pirimetamina/farmacologia,
Proteínas de Protozoários/genética,
Malária Falciparum/epidemiologia,
d0161330,
d0138120,
Moçambique/epidemiologia,
Ligases,
Combinação de Medicamentos,
Resistência a Medicamentos/genética,
Combinação Ezetimiba e Simvastatina/uso terapêutico,
Pirimetamina/provisão & distribuição,
Preparações Farmacêuticas,
Haplótipos/genética,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Plasmodium falciparum/efeitos da radiação,
Plasmodium falciparum/isolamento & purificação,
Proteínas de Protozoários/normas,
Sulfadoxina/farmacologia
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Cloroquina/efeitos adversos,
Amodiaquina/administração & dosagem,
Malária Falciparum/tratamento farmacológico,
Sulfadoxina/administração & dosagem,
Antimaláricos/administração & dosagem,
Antimaláricos/efeitos adversos,
Cloroquina/administração & dosagem,
Malária Falciparum/terapia,
Plasmodium falciparum/efeitos da radiação,
Pirimetamina/administração & dosagem,
Pirimetamina/efeitos adversos,
Resultado do Tratamento
Schellenberg, david;
Kahigwa, elizeus;
Drakeley, chris;
Malende, athumani;
Wigayi, John;
Msokame, chris;
Aponte, john J;
Tanner, marcel;
Mshinda, hassan;
Menendez, clara;
Alonso, pedro L.
The safety and efficacy of amodiaquine (AQ), sulfadoxine-pyrimethamine (SP), and coadministered AQ+SP was assessed in 351 Tanzanian children (age range, 6-59 months) with uncomplicated Plasmodium falciparum malaria. This open, randomized study followed the 28-day World Health Organization (WHO) protocol ...
